Details:

Alternative Title:
J Immunotoxicol
Publisher's site:
http://dx.doi.org/10.3109/1547691X.2011.654364
Personal Author:
Anderson, Stacey E. ; Tapp, Loren ; Durgam, Srinivas ; Meade, B. Jean ; Jackson, Laurel G. ; ... More +
Anderson, Stacey E. ; Tapp, Loren ; Durgam, Srinivas ; Meade, B. Jean ; Jackson, Laurel G. ; Cohen, David E. ; Less -
Description:
Skin diseases including dermatitis constitute ≈ 30% of all occupational illnesses, with a high incidence in the printing industry. An outbreak of contact dermatitis among employees at an ink ribbon manufacturing plant was investigated by scientists from the National Institute for Occupational Safety and Health (NIOSH). Employees in the process areas of the plant were exposed to numerous chemicals and many had experienced skin rashes, especially after the introduction of a new ink ribbon product. To identify the causative agent(s) of the occupational dermatitis, the murine local lymph node assay (LLNA) was used to identify the potential of the chemicals used in the manufacture of the ink ribbon to induce allergic contact dermatitis. Follow-up patch testing with the suspected allergens was conducted on exposed employees. Polyvinyl butyral, a chemical component used in the manufacture of the ink ribbon in question and other products, tested positive in the LLNA, with an EC3 of 3.6%, which identifies it as a potential sensitizer; however, no employees tested positive to this chemical during skin patch testing. This finding has implications beyond those described in this report because of occupational exposure to polyvinyl butyral outside of the printing industry.
Subject:
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Allergens
Animals
Dermatitis, Allergic Contact
Environmental Monitoring
Female
Humans
Immunization
Industry
Ink
Local Lymph Node Assay
Mice
Mice, Inbred BALB C
Occupational Exposure
Patch Tests

Source:
J Immunotoxicol. 9(2):193-200.
Pubmed ID:
22375946
Pubmed Central ID:
PMC4683595
Document Type:
Journal Article ;
Funding:
CC999999/Intramural CDC HHS/United States ;
Name as Subject:
National Institute for Occupational Safety and Health. ;
Place as Subject:
United States ;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:1d068417ef16a314d0ffaafe9421127e72571cfc2c6e8c6896f876b396438a78
File Type:

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