The LLNA: a brief review of recent advances and limitations

Details

• Personal Author:
  Anderson, Stacey E. ; Meade BJ ; Siegel, Paul D.
• Description:
  Allergic contact dermatitis is the second most commonly reported occupational illness, accounting for 10 percent to 15 percent of all occupational diseases. This highlights the importance of developing rapid and sensitive methods for hazard identification of chemical sensitizers. The murine local lymph node assay (LLNA) was developed and validated for the identification of low molecular weight sensitizing chemicals. It provides several benefits over other tests for sensitization because it provides a quantitative endpoint, dose-responsive data, and allows for prediction of potency. However, there are also several concerns with this assay including: levels of false positive responses, variability due to vehicle, and predictivity. This report serves as a concise review which briefly summarizes the progress, advances and limitations of the assay over the last decade. [Description provided by NIOSH]
• Subjects:
  Biological Assay Chemistry Dermatitis Health Care Facilities Workforce And Services Hypersensitivity Occupational Health Safety Skin Skin Diseases
• Keywords:
  Allergens Allergic-dermatitis Allergic-disorders Allergic-reactions Allergies Bioassays Chemical-hypersensitivity Chemical-reactions Dermatosis Dose-response Lymph-nodes Medical-monitoring Medical-screening Molecular-biology Molecular-structure Quantitative-analysis Sensitivity-testing Skin-diseases Skin-disorders Skin-exposure Skin-irritants Skin-lesions

  More +
• ISSN:
  1687-9783
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  2011
• NIOSHTIC Number:
  nn:20038941
• Citation:
  J Allergy 2011 Jan; 2011:424203
• Contact Point Address:
  Stacey E. Anderson, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Drive, Morgantown, WV 26505
• Email:
  dbx7@cdc.gov
• Federal Fiscal Year:
  2011
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Allergy
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:07eae7db4e7204665b4ff43a4f3051d7c49733fe79ada9c3b2f1fec2383038db228ab04d8b7353e431382638e1f953af4ae754df9816085f3c4d77669f228fc8
• Download URL:
  https://stacks.cdc.gov/view/cdc/192460/cdc_192460_DS1.pdf
• File Type:
  [PDF - 530.64 KB ]