Distinguishing the common components of oil- and water-based metalworking fluids for assessment of cancer incidence risk in autoworkers

Details

• Personal Author:
  Costello S ; Eisen EA ; Friesen MC ; Thurston SW
• Description:
  Background: Metalworking fluids (MWF) - straight, soluble, and synthetic - have overlapping components. We derived constituent-based metrics of polycyclic aromatic hydrocarbons (PAHs), water-based MWF, biocides, and nitrosamines to account for this overlap and examined their relations with cancer incidence. Methods: An autoworkers cohort of 30,000 was followed for cancer incidence. Hazard ratios were estimated for each cancer and cumulative exposure (lagged) to each new metric; soluble MWF contributed variably to several metrics with weight k = 0-1. Results: For most cancer sites, the constituent-based metrics resulted in stronger exposure-disease associations than the MWF classes alone. Laryngeal and bladder cancer were most strongly associated with PAH (k = 0). Protective effects for stomach and lung cancer were observed with biocide, a component that may be a surrogate for endotoxin. Conclusions: Our findings provide support and clarification of possible etiologies for previous positive associations and provide support for distinguishing exposure from oil- and water-based MWF in epidemiologic studies. [Description provided by NIOSH]
• Subjects:
  Automobiles Environmental Monitoring Epidemiology Hazardous Substances Hypersensitivity Metals Metal Workers Mortality Neoplasms Occupational Diseases Occupational Exposure Occupational Health Poisoning Risk Assessment Safety Workplace

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• Keywords:
  Analytical-processes Author Keywords: Metalworking Fluids Automotive-industry Biocides Biohazards Biological-effects Biological-monitoring Biological-systems Biostatistics Cancer-rates Cancer Incidence Chemical-hypersensitivity Cohort Study Endotoxin Exposure-assessment Exposure-levels Exposure-methods Metal-compounds Metal-industry-workers Metal-poisoning Metal-workers Metalworking-fluids Metalworking-industry Mortality-data Mortality-rates Nitrosamines Occupational-diseases Occupational-exposure Occupational-hazards Occupational-health Polycyclic Aromatic Hydrocarbons Quantitative-analysis Risk-analysis Statistical-analysis Work-areas Work-environment Work-operations Work-organization Work-performance Worker-health Workplace-studies

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• ISSN:
  0271-3586
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Maryland ; OSHA Region 3 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  450-460
• Volume:
  54
• Issue:
  6
• NIOSHTIC Number:
  nn:20039592
• Citation:
  Am J Ind Med 2011 Jun; 54(6):450-460
• Contact Point Address:
  Ellen A. Eisen, ScD, Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720-7360
• Email:
  eeisen@berkeley.edu
• Federal Fiscal Year:
  2011
• Performing Organization:
  University of California, Berkeley
• Peer Reviewed:
  True
• Start Date:
  20070801
• Source Full Name:
  American Journal of Industrial Medicine
• End Date:
  20100731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1d0712f804e8ebc9c60002b836451f4dc9da50f330915d84accc51d2307e690805734fe8121d8f69e32f4205cbb578c121a78684e02421cd6dc3259541791188
• Download URL:
  https://stacks.cdc.gov/view/cdc/192783/cdc_192783_DS1.pdf
• File Type:
  [PDF - 287.56 KB ]