The two-stage clonal expansion model in occupational cancer epidemiology: results from three cohort studies

Details

• Personal Author:
  Gore R ; Kriebel D ; Zeka A
• Description:
  Objectives: The objective of this work was to apply the two-stage clonal expansion model, with the intention to expand the literature on epidemiological applications of the model and demonstrate the feasibility of incorporating biologically based modelling methods into the widely used retrospective cohort study. Methods: The authors fitted the two-stage clonal expansion model model to three occupational cohort studies: (1) a cohort of textile workers exposed to asbestos and followed for lung cancer mortality; (2) a cohort of diatomaceous earth workers exposed to silica and also followed for lung cancer mortality; and (3) a cohort of automotive manufacturing workers exposed to straight metalworking fluid (MWF) and followed for larynx cancer incidence. The model allowed the authors to estimate exposure effects in three stages: cancer initiation (early effects), promotion or malignant transformation (late effects). Results: In the first cohort, the authors found strong evidence for an early effect of asbestos on lung cancer risk. Findings from analyses of the second cohort suggested early and less evidently late effects of silica on lung cancer risk. In the MWF (third) cohort, there was only weak evidence of straight MWF exposure effects on both early and late stages. The authors also observed a late birth cohort effect on larynx cancer risk. Conclusions: The findings for asbestos and silica were essentially confirmatory, supporting evidence for their early effects on lung cancer from a large body of literature. The effect of straight MWF on larynx cancer was less clear. [Description provided by NIOSH]
• Subjects:
  Automobiles Carcinogens Environmental Monitoring Epidemiology Hazardous Substances Lung Lung Diseases Metals Metal Workers Mortality Neoplasms Occupational Diseases Occupational Exposure Occupational Health Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Solvents Workplace

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• Keywords:
  Analytical-processes Automotive-industry Biohazards Biological-effects Biological-monitoring Biological-systems Biostatistics Cancer Cancer-rates Carcinogenesis Carcinogenicity Exposure-assessment Exposure-levels Exposure-methods Larynx-cancer Lung-cancer Lung-disorders Metal-compounds Metal-fumes Metal-industry-workers Metal-workers Metalworking Metalworking-fluids Metalworking-industry Models Mortality-data Mortality-rates Mortality-surveys Occupational-diseases Occupational-exposure Occupational-hazards Occupational-health Pulmonary-system-disorders Quantitative-analysis Respiratory-system-disorders Risk-analysis Risk-factors Statistical-analysis Vapors Work-areas Work-environment Work-operations Work-organization Work-performance Worker-health Workplace-studies

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• ISSN:
  1351-0711
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  68
• Issue:
  8
• NIOSHTIC Number:
  nn:20039593
• Citation:
  Occup Environ Med 2011 Aug; 68(8):618-624
• Contact Point Address:
  Dr Ariana Zeka, Institute for the Environment, Brunel University, Halsbury 149, Uxbridge UB8 3PH, UK
• Email:
  ariana.zeka@brunel.ac.uk
• CAS Registry Number:
  Asbestos (CAS RN 1332-21-4) ; Silica (CAS RN 7631-86-9)
• Federal Fiscal Year:
  2011
• Performing Organization:
  University of Massachusetts Lowell
• Peer Reviewed:
  True
• Start Date:
  19990801
• Source Full Name:
  Occupational and Environmental Medicine
• End Date:
  20020731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:20bbfb820bc649f9896f8b12aa82cedf7a4ff5b79aab926e3169b13e5563df276a3d88cdb4eabf68b518bdd6e43599a1d6f8fd099f249ceb41ab5081d7b83e7c
• Download URL:
  https://stacks.cdc.gov/view/cdc/192784/cdc_192784_DS1.pdf
• File Type:
  [PDF - 136.46 KB ]