Quantitative Exposure to Metalworking Fluids and Bladder Cancer Incidence in a Cohort of Autoworkers

Details

• Personal Author:
  Costello S ; Eisen EA ; Friesen MC
• Description:
  Occupations with mineral oil exposure have been associated with bladder cancer in population-based case-control studies. The authors report results from the first cohort study to examine bladder cancer incidence in relation to quantitative exposures to metalworking fluids (MWFs), based on 21,999 male Michigan automotive workers, followed from 1985 through 2004. Cox regression was used to estimate hazard ratios based on categorical exposure variables for straight, soluble, and synthetic MWFs, as well as duration of exposure to ethanolamines and nitrosamines. Penalized splines were also fit to estimate the functional form of the exposure-response relation. Increased bladder cancer risk was associated with straight MWFs but not with any other exposure. The hazard ratio increased with cumulative exposure to a maximum of 2-fold observed at 75 mg/m(3)-year straight MWF exposure (lagged 20 years). Calendar time windows relevant to polycyclic aromatic hydrocarbon exposure were examined but could not be distinguished from the lagged (10-, 20-year) metrics. No association was observed between any exposure and incident lung cancer, suggesting that smoking is unlikely to confound the associations observed here. The quantitative relation with straight MWFs strengthens the evidence for mineral oils as a bladder carcinogen. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Automobiles Chemistry Environmental Monitoring Epidemiology Hazardous Substances Hypersensitivity Irritants Metals Metal Workers Mineral Oil Neoplasms Occupational Diseases Occupational Exposure Occupational Health Particulate Matter Poisoning Risk Assessment Safety Urogenital Diseases Urogenital System Workplace

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• Keywords:
  Airborne-particles Aromatic Author Keywords: Cohort Studies Automotive-industry Biohazards Biological-monitoring Biological-systems Bladder-cancer Bladder-disease Bladder-disorders Cancer Cancer-rates Chemical-hypersensitivity Chemical-properties Cox Model Ethanolamines Exposure-assessment Exposure-levels Exposure-methods Lung Neoplasms Metal-compounds Metal-industry-workers Metal-poisoning Metal-workers Metalworking-fluids Metalworking-industry Mineral Oil Nitrosamines Occupational-diseases Occupational-exposure Occupational-hazards Occupational-health Polycyclic Hydrocarbons Quantitative-analysis Respiratory-irritants Risk-analysis Statistical-analysis Urinary Bladder Neoplasms Urogenital-system-disorders Work-environment Work-operations Worker-health Workplace-studies

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• ISSN:
  0002-9262
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Maryland ; OSHA Region 3 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  169
• Issue:
  8
• NIOSHTIC Number:
  nn:20035555
• Citation:
  Am J Epidemiol 2009 Jun; 169(12):1471-1478
• Contact Point Address:
  Dr. Ellen A. Eisen, Environmental Health Sciences Division, School of Public Health, University of California, 50 University Hall, #7360, Berkeley, CA 94720-7360
• Email:
  eeisen@berkeley.edu
• CAS Registry Number:
  Ethanolamine (CAS RN 141-43-5) ; Tetryl (CAS RN 479-45-8)
• Federal Fiscal Year:
  2009
• Performing Organization:
  University of California, Berkeley
• Peer Reviewed:
  True
• Start Date:
  20070801
• Source Full Name:
  American Journal of Epidemiology
• End Date:
  20100731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:256813ca16c564deebce7828ab1f2b3c344add3e86be47d131ba608388a81215a9b69790da6b431a2e9853b8aa3116761d0f4b79dd134a40f489460e3cb4a0c7
• Download URL:
  https://stacks.cdc.gov/view/cdc/187379/cdc_187379_DS1.pdf
• File Type:
  [PDF - 127.81 KB ]