Immunoassays and biosensors for monitoring environmental and human exposure to pyrethroid insecticides

Details

• Personal Author:
  Ahn KC ; Gee SJ ; Hammock BD ; Kim H-J ; McCoy MR
• Description:
  This paper describes some of the early work on pyrethroid insecticides in the Casida laboratory and briefly reviews the development and application of immunochemical approaches for the detection of pyrethroid insecticides and their metabolites for monitoring environmental and human exposure. Multiple technologies can be combined to enhance the sensitivity and speed of immunochemical analysis. The pyrethroid assays are used to illustrate the use of some of these immunoreagents such as antibodies, competitive mimics, and novel binding agents such as phage-displayed peptides. The paper also illustrates reporters such as fluorescent dyes, chemiluminescent compounds, and luminescent lanthanide nanoparticles, as well as the application of magnetic separation, and automatic instrumental systems, biosensors, and novel immunological technologies. These new technologies alone and in combination result in an improved ability to both determine if effective levels of pyrethroids are being used in the field and evaluate possible contamination. [Description provided by NIOSH]
• Subjects:
  Body Fluids Environmental Exposure Immune System Insecticides Occupational Health Safety
• Keywords:
  Analytical Methods Author Keywords: Pyrethroid Insecticides Biomonitoring Biosensors Body Fluids Environmental Exposure Immunoassay Immunochemistry Monitoring Pesticides And Agricultural Chemicals Sensors

  More +
• ISSN:
  0021-8561
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  59
• Issue:
  7
• NIOSHTIC Number:
  nn:20039406
• Citation:
  J Agric Food Chem 2011 Apr; 59(7):2792-2802
• Contact Point Address:
  Bruce D. Hammock, Department of Entomology, University of California, Davis, Davis, California 95616
• Email:
  bdhammock@ucdavis.edu
• Federal Fiscal Year:
  2011
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of California - Davis
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  Journal of Agricultural and Food Chemistry
• End Date:
  20270929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:db1ab7f3b740d0b3f79b703a453357c41016eb6bc3fad4e80fe171e851863aa3ce6833d6c38fbbdd0e37be48d3abc1718bc0d6e7ed7078fb082e403288d3f8b6
• Download URL:
  https://stacks.cdc.gov/view/cdc/192701/cdc_192701_DS1.pdf
• File Type:
  [PDF - 1.74 MB ]