Pesticide/Environmental Exposures and Parkinson’s Disease in East Texas

Details

• Personal Author:
  Dhillon AS ; Levin, Jeffrey L. ; Lowry, Larry K. ; Nalbone JT ; Plotkin GM ; Shepherd S ; Tarbutton GL
• Description:
  Epidemiological evidence suggests that pesticides and other environmental exposures may have a role in the etiology of idiopathic Parkinson's disease (PD). However, there is little human data on risk associated with specific pesticide products, including organic pesticides such as rotenone with PD. Using a case-control design, this study examined self-reports of exposure to pesticide products, organic pesticides such as rotenone, and other occupational and environmental exposures on the risk of PD in an East Texas population. The findings demonstrated significantly increased risk of PD with use of organic pesticides such as rotenone in the past year in gardening (OR = 10.9; 95% CI = 2.5-48.0) and any rotenone use in the past (OR = 10.0; 95% CI = 2.9-34.3). Use of chlorpyrifos products (OR = 2.0; 95% CI = 1.02-3.8), past work in an electronics plant (OR = 5.1; 95% CI = 1.1-23.6), and exposure to fluorides (OR = 3.3; 95% CI = 1.03-10.3) were also associated with significantly increased risk. A trend of increased PD risk was observed with work history in paper/lumber mill (OR = 6.35; 95% CI = 0.7-51.8), exposure to cadmium (OR = 5.3; 95% CI = 0.6-44.9), exposure to paraquat (OR = 3.5; 95% CI = 0.4-31.6), and insecticide applications to farm animals/animal areas and agricultural processes (OR = 4.4; 95% CI = 0.5-38.1). Cigarette smoking, alcohol use, and fish intake were associated with reduced risk. In summary, this study demonstrates an increased risk of PD associated with organic pesticides such as rotenone and certain other pesticides and environmental exposures in this population. [Description provided by NIOSH]
• Subjects:
  Agriculture Environmental Exposure Epidemiology Insecticides Occupational Health Safety
• Keywords:
  Environmental Exposure Environmental Health Monitoring Pesticides And Agricultural Chemicals Toxic Effects
• ISSN:
  1059-924X
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 6 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  49-58
• Volume:
  13
• Issue:
  1
• NIOSHTIC Number:
  nn:20034748
• Citation:
  J Agromedicine 2008 Jan; 13(1):37-48
• Contact Point Address:
  Department of Occupational Health Sciences, University of Texas Health Science Center at Tyler, Tyler, Texas 75708
• Email:
  amanpreet.dhillon@uthct.edu
• Federal Fiscal Year:
  2008
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Texas Health Center at Tyler
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  Journal of Agromedicine
• End Date:
  20270929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0cd69f4f8d45df2e57d07e53a728201e0871e544e19722fb6c281a3675b84edbccc342a8982d063ad45738825731b77137ac9c37d74e1784fe39cfe8c287a54d
• Download URL:
  https://stacks.cdc.gov/view/cdc/186841/cdc_186841_DS1.pdf
• File Type:
  [PDF - 239.20 KB ]