Pharmacokinetics of Vhlorpyrifos Metabolites in Saliva

Details

• Personal Author:
  Campbell JA ; Poet TS ; Smith JN ; Timchalk CA
• Description:
  Non-invasive techniques have been advocated as a novel means of biomonitoring for a variety of potential toxicants, including pesticides; and saliva has been suggested as an ideal body fluid. There is a critical need to evaluate pharmacokinetics of pesticides in saliva in order to relate potential saliva sensor measurements to whole body exposures. Within this project, we quantitatively evaluated in vivo pharmacokinetics of trichloropyridinol (TCPy), a metabolite of the insecticide chlorpyrifos (CPF), in saliva. Using microsurgical techniques, mean (+/- SD) salivary clearance rates of TCP were determined to be 0.0049 +/- 0.0056 and 0.0040 +/- 0.0019 mL/min for rats receiving IV bolus doses of TCPy at 1 mg/kg and 10 mg/kg, respectively. Similar rates indicate a linear relationship of salivary TCPy clearance between dose groups. Data generated are being incorporated into an existing physiologically based pharmacokinetic and pharmacodynamic (PBPK/ PD) model. This model can be coupled with sensor platforms and used to estimate both concentrations and pharmacodynamic effects of CPF and CPF metabolites in blood and target organs. It is envisioned that this approach will be used to monitor agricultural workers that are at risk from acute and chronic pesticide occupational exposure. [Description provided by NIOSH]
• Subjects:
  Agriculture Animals Blood Body Fluids Energy Metabolism Environmental Exposure Hazardous Substances Insecticides Laboratories Occupational Health Safety

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• Keywords:
  Agricultural Chemicals Agricultural Workers Biomonitoring Body Fluids Chlorpyrifos Exposure Levels Laboratory Animals Metabolites Models Pesticides Pharmacodynamics Sensors Toxins

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• Publisher:
  University of Washington
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 10 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1
• NIOSHTIC Number:
  nn:20050548
• Citation:
  Proceedings of Health and Safety in Western Agriculture: New Paths, November 11-13, 2008, Cle Elum, Washington. Seattle, WA, Washington University, 2008 Nov; :1
• CAS Registry Number:
  Chlorpyrifos (CAS RN 2921-88-2)
• Federal Fiscal Year:
  2009
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  Battelle Pacific Northwest Laboratories
• Peer Reviewed:
  False
• Start Date:
  20060901
• Source Full Name:
  Proceedings of Health and Safety in Western Agriculture: New Paths, November 11-13, 2008, Cle Elum, Washington
• End Date:
  20170831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:48adcb1ace730873374a5a7533461e27900e07b994c7a7e4bb4e2ed7bbe2d242a47beb39bb481a94e5c88cc7663b5c69cc61deeb32dd26aa02113d97786b6647
• Download URL:
  https://stacks.cdc.gov/view/cdc/210851/cdc_210851_DS1.pdf
• File Type:
  [PDF - 1.09 MB ]