National study of exposure to pesticides among professional applicators: an investigation based on urinary biomarkers

Details

• Personal Author:
  Crawley CD ; Harris SA ; Hurto KA ; Mays JE ; Meeker JD ; Villeneuve PJ ; Yeary RA
• Description:
  Epidemiologic studies of pesticides have been subject to important biases arising from exposure misclassification. Although turf applicators are exposed to a variety of pesticides, these exposures have not been well characterized. This paper describes a repeated measures study of 135 TruGreen applicators over three spraying seasons via the collection of 1028 urine samples. These applicators were employed in six cities across the United States. Twenty-four-hour estimates (µg) were calculated for the parent compounds 2,4-D, MCPA, mecoprop, dicamba, and imidacloprid and for the insecticide metabolites MPA and 6-CNA. Descriptive statistics were used to characterize the urinary levels of these pesticides, whereas mixed models were applied to describe the variance apportionment with respect to city, season, individual, and day of sampling. The contributions to the overall variance explained by each of these factors varied considerably by the type of pesticide. The implications for characterizing exposures in these workers within the context of a cohort study are discussed. [Description provided by NIOSH]
• Subjects:
  Biochemistry Biomarkers Chemistry Energy Metabolism Environmental Monitoring Epidemiology Insecticides Occupational Exposure Occupational Health Safety Urine

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• Keywords:
  Analytical-models Author Keywords: Occupational Exposure Biochemical-analysis Biological Monitoring Chemical-analysis Chemical-indicators Exposure-assessment Exposure Assessment Methods Metabolites Mixed Models Pest-control Pesticide-residues Pesticides Pharmacodynamics Pyrethroids Sampling Seasonal-factors Sprays Urinalysis Urine

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• ISSN:
  0021-8561
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; Ohio ; OSHA Region 3 ; OSHA Region 5 ; Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  58
• Issue:
  18
• NIOSHTIC Number:
  nn:20038179
• Citation:
  J Agric Food Chem 2010 Sep; 58(18):10253-10261
• Contact Point Address:
  Shelley A. Harris, Population Studies and Surveillance, Cancer Care Ontario, 620 University Ave., Toronto, ON, Canada M5G2L7
• Email:
  Shelley.Harris@cancercare.on.ca
• CAS Registry Number:
  (2,4-Dichlorophenoxy)acetic acid (CAS RN 94-75-7) ; (4-Chloro-2-methylphenoxy)acetic acid (CAS RN 94-74-6) ; 6-Chloronicotinic acid (CAS RN 5326-23-8) ; Bifenthrin (CAS RN 82657-04-3) ; Dicamba (CAS RN 1918-00-9) ; Imidacloprid (CAS RN 138261-41-3) ; Mecoprop (CAS RN 93-65-2)
• Federal Fiscal Year:
  2010
• Performing Organization:
  Virginia Commonwealth University, Richmond, Virginia
• Peer Reviewed:
  True
• Start Date:
  20020801
• Source Full Name:
  Journal of Agricultural and Food Chemistry
• End Date:
  20050731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:578a421bb732cb7e25b10543de17b640e1ce214d56779b16fa8b40f8a0214251fea5056ac06a363041bfb2177faff9252de7c26841a3c65b1131e5cbe9e75696
• Download URL:
  https://stacks.cdc.gov/view/cdc/191969/cdc_191969_DS1.pdf
• File Type:
  [PDF - 1.55 MB ]