i
Pneumocystis jirovecii Genotype Associated with Increased Death Rate of HIV-infected Patients with Pneumonia
-
Published Date:
Jan 2013
Source:Emerg Infect Dis. 19(1):21-28.Language:English -
Alternative Title:Emerg Infect Dis
-
Personal Author:
-
Description:Pneumocystis jirovecii dihydropteroate synthase (DHPS) mutations have been associated with failure of sulfa prophylaxis; their effect on the outcome of patients with P. jirovecii pneumonia (PCP) remains controversial. P. jirovecii DHPS polymorphisms and genotypes were identified in 112 cases of PCP in 110 HIV-infected patients by using PCR single-strand conformation polymorphism. Of the 110 patients observed, 21 died; 18 of those deaths were attributed to PCP. Thirty-three percent of the PCP cases involved a P. jirovecii strain that had 1 or both DHPS mutations. The presence or absence of DHPS mutations had no effect on the PCP mortality rate within 1 month, whereas P.jirovecii type 7 and mechanical ventilation at PCP diagnosis were associated with an increased risk of death caused by PCP. Mechanical ventilation at PCP diagnosis was also associated with an increased risk of sulfa treatment failure at 5 days.
-
Subject:
-
Document Type:
-
Collection(s):
-
Main Document Checksum:
-
File Type:
-
Supporting Files:
image/gif 
image/jpeg 
text/plain
text/plain
[PDF-869.37 KB]
Details:
No Related Documents.
You May Also Like:
-
[PDF - 243.73 KB]
Published Date:Source:Description:File Type:[PDF - 243.73 KB]
File Type:[PDF - 243.73 KB]
[PDF - 141.41 KB]
Published Date:Source:Description:File Type:[PDF - 141.41 KB]
File Type:[PDF - 141.41 KB]
[PDF - 528.62 KB]
Published Date:Source:Description:File Type:[PDF - 528.62 KB]
File Type:[PDF - 528.62 KB]
[PDF - 570.05 KB]
Published Date:Source:Description:File Type:[PDF - 570.05 KB]
File Type:[PDF - 570.05 KB]
[PDF - 246.20 KB]
Published Date:Source:Description:File Type:[PDF - 246.20 KB]
File Type:[PDF - 246.20 KB]
Have Questions?
Visit CDC Info
Email
CDC-INFO
Open 24/7
CDC INFORMATION
CONNECT WITH CDC
