Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Rabodonirina, Meja ; Vaillant, Laetitia ; Taffé, Patrick ; Nahimana, Aimable ; Gillibert, René-Pierre ; ... More +
Rabodonirina, Meja ; Vaillant, Laetitia ; Taffé, Patrick ; Nahimana, Aimable ; Gillibert, René-Pierre ; Vanhems, Philippe ; Hauser, Philippe M. Less -
Description:
Pneumocystis jirovecii dihydropteroate synthase (DHPS) mutations have been associated with failure of sulfa prophylaxis; their effect on the outcome of patients with P. jirovecii pneumonia (PCP) remains controversial. P. jirovecii DHPS polymorphisms and genotypes were identified in 112 cases of PCP in 110 HIV-infected patients by using PCR single-strand conformation polymorphism. Of the 110 patients observed, 21 died; 18 of those deaths were attributed to PCP. Thirty-three percent of the PCP cases involved a P. jirovecii strain that had 1 or both DHPS mutations. The presence or absence of DHPS mutations had no effect on the PCP mortality rate within 1 month, whereas P.jirovecii type 7 and mechanical ventilation at PCP diagnosis were associated with an increased risk of death caused by PCP. Mechanical ventilation at PCP diagnosis was also associated with an increased risk of sulfa treatment failure at 5 days.
Subject:
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Adolescent Adult Aged Aged, 80 And Over Antibiotic Antifungal Drugs Antimicrobial Drugs Atovaquone Child, Preschool CME Coinfection Dapsone DHPS Dihydropteroate Synthase Dihydropteroate Synthase Mutations Drug Resistance, Fungal Female France Fungal Fungal Proteins Fungi Fungus HIV HIV Infections Homosexuality Humans Immunocompromised Infant Intravenous Drug Use Male Middle Aged Mutation Opportunistic Infection Pentamidine Pneumocystis Jirovecii Pneumocystis Jirovecii Dihydropteroate Synthase Pneumocystis Jirovecii Pneumonia Pneumonia, Pneumocystis Research Respiration, Artificial SMX/TMP Sulfamethoxazole/trimethoprim Sulfa Resistance Survival Rate Trimethoprim-Sulfamethoxazole Combination Virus
Source:
Emerg Infect Dis. 19(1):21-28.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:0687b88b8306d0119ed7040f1efe06e76f4e94baf257c01e2a1900a53d6e0e72
Download URL:
https://stacks.cdc.gov/view/cdc/18744/cdc_18744_DS1.pdf
File Type:

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