A Comparison of the Pulmonary Inflammatory Potential of Different Components of Yeast Cell Wall

Details

• Personal Author:
  Antonini JM ; Castranova, Vincent ; Ostroff GR ; Roberts, Jennifer R. ; Young S-H ; Zeidler-Erdely PC
• Description:
  1-->3-Beta-Glucan has been associated with pulmonary inflammation induced by exposure to fungal or yeast cell wall dust. 1-->3-Beta-Glucan is the major cell wall component of yeast or fungi. However, the yeast cell wall contains several other components besides 1-->3-Beta-glucans, such as mannan and chitin. Few studies evaluated the contribution of these other cell wall components to pulmonary inflammation. The present study compares a crude particulate yeast cell wall preparation (zymosan A) to purified yeast glucan, purified yeast glucan mannan, or purified yeast glucan chitin particles for their potency to induce mouse pulmonary inflammation after in vivo exposure. Mannan is the second most abundant polysaccharide in the yeast cell wall, whereas chitin content is a minor component. The results show that pulmonary injury is mediated by both chitin and 1-->3-Beta-glucan and to a lesser degree by mannan. There is also evidence that zymosan is more potent than purified 1-->3-Beta-glucan alone. Evidence indicates that 1-->3-Beta-glucan is the major inflammatory component in yeast and fungal cell walls. [Description provided by NIOSH]
• Subjects:
  Animals Dust Fungi Lung Lung Diseases Occupational Health Particulate Matter Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Animal-studies Cell-damage Cell-function Cell-wall-permeability Cellular-transport-mechanism Dust-inhalation Dust-particles Fungal-diseases Fungal-infections Particle-aerodynamics Particulate-dust Pulmonary-disorders Pulmonary-system-disorders

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• ISSN:
  1528-7394
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1 ; OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  70
• Issue:
  13
• NIOSHTIC Number:
  nn:20032076
• Citation:
  J Toxicol Environ Health A 2007 Jan; 70(13):1116-1124
• Contact Point Address:
  Shih-Houng Young, PhD, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road (M/S 2015), Morgantown, WV 26505
• Email:
  sby5@cdc.gov
• Federal Fiscal Year:
  2007
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Toxicology and Environmental Health, Part A: Current Issues
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a27955e390c98c59ce279dfa6d854cb50b5dbbd6ee49471dfb676763b1ea1cee7cfce899900391122d4ace36fd62dbbd0628fc88d16dc4d72d9efeb08dadc373
• Download URL:
  https://stacks.cdc.gov/view/cdc/186141/cdc_186141_DS1.pdf
• File Type:
  [PDF - 933.30 KB ]