Toxicity of penicillic acid for rat alveolar macrophages in vitro.

Details

• Personal Author:
  Simpson J ; Sorenson WG ; Simpson J ; Sorenson WG
• Description:
  The cytotoxic effects of penicillic-acid (90653) (PA) were tested in cultured alveolar cell macrophages harvested from male Long-Evans- hooded-rats by tracheal lavage. There was significant release of chromium-51 from labeled cells after 2 hours of exposure to 1 millimolar (mM) PA, but not after 2 hours; the levels of adenosine- triphosphate in the culture declined significantly after 4 hours of exposure. Dose dependent inhibition of tritiated leucine into proteins and of protein synthesis after 2 hours of exposure to 2mM PA or more was observed. Inhibition of RNA synthesis was less pronounced than that of protein synthesis at 1mM PA after 4 hours, and concentrations lower than 1mM did not affect this parameter. After 2 hours of exposure, the median effective doses for protein and RNA synthesis inhibition were 0.18 and 0.60mM, respectively. The median effective dose of PA on phagocytosis, which was inhibited by exposure to doses equal to or greater than 0.03mM, proved to be lower than those of all the other parameters studied and amounted to macrophages and suggest that the agent may be a hazard to agricultural workers exposed to contaminated grains. [Description provided by NIOSH]
• Subjects:
  Cytotoxins Laboratories Lung Mycoses Occupational Health Respiratory System Safety Toxicology
• Keywords:
  Alveolar-cells Cellular-function Cytotoxic-effects Dose-response In-vitro-studies Laboratory-animals Mycotoxins Natural-products NIOSH-Author Pulmonary-system
• ISSN:
  0013-9351
• Document Type:
  Text
• Genre:
  Journal Article ; Journal Article
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Volume:
  41
• Issue:
  2
• NIOSHTIC Number:
  nn:00170247
• Citation:
  Environ Res 1986 Dec; 41(2):505-513
• CAS Registry Number:
  Penicillic acid (CAS RN 90-65-3) ; Penicillic acid (CAS RN 90-65-3)
• Federal Fiscal Year:
  1987
• NORA Priority Area:
  Pulmonary System Disorders ; Pulmonary System Disorders
• Peer Reviewed:
  True
• Source Full Name:
  Environmental Research
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e8c420da32c0195176250e43b62749215e19de4e1462bd1a9f731a456c6bbfc7eab33dec34fa843ec8c2679bbd49386e2e490bd4d8183459bd85eaa397a45473
• Download URL:
  https://stacks.cdc.gov/view/cdc/185213/cdc_185213_DS1.pdf
• File Type:
  [PDF - 532.63 KB ]