Pharmacologic studies of paper dust extracts in isolated guinea pig trachea.

Details

• Personal Author:
  Ali S ; Buck MG ; Castranova, Vincent ; Goswami SK ; Maayani S ; Rienzi N ; Schachter E ; Siegel P ; Wan E ; Whitmer M ; Zuskin E
• Description:
  The pharmacologic properties of water soluble extracts of paper dust (PDE) were investigated using isolated guinea-pig trachea. Dose response relationships between PDEs and contraction of guinea-pig tracheal smooth muscle were established. Paper dust was obtained from separate sites in a paper recycling mill, both early and later in the process. Pretreatment with mediator blockers, arachidonic- acid metabolite inhibitors, and an intracellular calcium antagonist were examined and compared to findings with similar experiments using cotton bract extracts. The effect of pretreatment with capsaicin was also assessed. Contraction induced by paper dust extract collected early in the process was partially inhibited by all the mediator inhibiting agents as well as the receptor blocking agents with the exception of LY-171883. Similar findings were noted for paper dust extract collected late in the process, except that pyrilamine and indomethacin failed to block the bronchoconstrictor effect. Pretreatment with capsaicin enhanced the effects of both early and late paper dust extract. The authors suggest that water soluble extracts from the paper recycling industry cause airway smooth muscle constriction via mediator release. [Description provided by NIOSH]
• Subjects:
  Cytotoxins Dust Laboratories Lung Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  NIOSH-Publication; NIOSH-Grant; Laboratory-animals; Respiratory-system-disorders; Lung-irritants; In-vitro-studies; Alveolar-cells; Lung-cells; Cytotoxic-effects; Organic-dusts
• ISSN:
  0897-5531
• Publisher:
  National Cotton Council
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Proceedings
• Place as Subject:
  New York ; OSHA Region 2 ; OSHA Region 4 ; Tennessee
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  363-365
• NIOSHTIC Number:
  nn:00240961
• Citation:
  Cotton Dust: Proceedings of the Twentieth Cotton and Other Organic Dusts Research Conference, 1996 Beltwide Cotton Conferences. Wakelyn P, Jacobs R, Rylander R, eds., Memphis, TN: National Cotton Council, 1996 Jan; :363-365
• Contact Point Address:
  Medicine Mount Sinai Medical Center One Gustave L Levy Place New York, N Y 10029
• Editor(s):
  Wakelyn P; Jacobs R; Rylander R
• Federal Fiscal Year:
  1996
• NORA Priority Area:
  Pulmonary System Disorders
• Performing Organization:
  Mount Sinai School of Medicine, New York, New York
• Peer Reviewed:
  False
• Start Date:
  19880701
• Source Full Name:
  Cotton Dust: Proceedings of the Twentieth Cotton and Other Organic Dusts Research Conference, 1996 Beltwide Cotton Conferences
• End Date:
  20020331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/243641/cdc_243641_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]