Inhalation toxicity of methyl n-amyl ketone (2-heptanone) in rats and monkeys.

Details

• Personal Author:
  Kommineni C ; Lewis TR ; Lynch DW ; Moorman WJ ; Plotnick HB ; Shuler RL ; Smallwood, Anthony W.
• Description:
  The effect of methyl-n-amyl-ketone (110430) (MAK) on cardiopulmonary function, clinical chemistry, metabolism, and tissue distribution was studied in Sprague-Dawley-rats and Cynomolgus-monkeys. Animals were exposed to mean MAK concentrations of 100 or 1000 parts per million for 6 hours per day for 1, 3, 6, or 10 months for rats, and 10 months for monkeys. Both species tolerated the exposures without overt signs of toxicity. No gross or microscopic exposure related changes in organs and tissues from either species were seen. No effect on dynamic compliance, inspiratory capacity, expiratory flow maximum or diffusion capacity occurred in monkeys. There were no dose related alterations in clinical chemistry. In metabolic studies, MAK was detected in both serum and urine from rats and monkeys exposed to both concentrations of MAK. In tissue distribution studies, carbon-14 labeled MAK accumulated primarily in the liver, followed by kidney, pancreas, and lung. Urinary excretion peaked at 12 hours and remained relatively constant through 48 hours. Fecal excretion through 72 hours represented less than 2 percent of the administration dose. The authors conclude that MAK does not produce cardiopulmonary or clinical chemical changes at the doses studied. [Description provided by NIOSH]
• Subjects:
  Biochemistry Cardiovascular System Energy Metabolism Laboratories Occupational Health Respiratory System Safety Solvents Somatotypes Toxicology
• Keywords:
  Body-distribution Cardiopulmonary-function Comparative-toxicology Laboratory-animals Metabolism NIOSH-Author Organic-solvents
• ISSN:
  0041-008X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Maine ; Ohio ; OSHA Region 1 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  341-352
• Volume:
  58
• Issue:
  3
• NIOSHTIC Number:
  nn:00115848
• Citation:
  Toxicol Appl Pharmacol 1981 May; 58(3):341-352
• CAS Registry Number:
  2-Heptanone (CAS RN 110-43-0)
• Federal Fiscal Year:
  1981
• Peer Reviewed:
  True
• Source Full Name:
  Toxicology and Applied Pharmacology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9f6b5e2970ac1a06399f054e52761786692118b9c7d9d0ecf6c5ff55c23900fb5e15b9cc2abc1af71211b46c336458ebcd25817cb049f5c5c7874fa6c5f8402e
• Download URL:
  https://stacks.cdc.gov/view/cdc/184446/cdc_184446_DS1.pdf
• File Type:
  [PDF - 1.04 MB ]