Effect of acrylamide intoxication on pyridine nucleotide concentrations and functions in rat cerebral cortex.

Details

• Personal Author:
  Johnson EC ; Murphy SD
• Description:
  The effect of acrylamide (79061) on pyridine nucleotide concentrations was studied in male Holtzman-rats. Animals were administered 40 milligrams per kilogram (mg/kg) per week of acrylamide and were sacrificed when the total cumulative dose was 428 or 668mg/kg. Rats given the lower cumulative dose developed mild symptoms of intoxication characterized by decreased body tone and increased excitability. Animals receiving the higher dose were more severely affected. While nicotinamide-adenine-dinucleotide- phosphate concentrations remained constant, nicotinamide-adenine- dinucleotide (NAD) concentrations showed a dose-related increase in the treated rats. NAD concentrations were significantly higher than controls in the high dose animals. Of the substrates, only the increase in alpha-glycerophosphate in the high dose rats was significant. There were no significant differences between control and treated rats for any high-energy phosphate source. The authors suggest that lipid metabolism may be affected in acrylamide intoxication. [Description provided by NIOSH]
• Subjects:
  Biochemistry Energy Metabolism Laboratories Occupational Health Safety Toxicology
• Keywords:
  Dose-response Grants-other Laboratory-animals Metabolism NIOSH-Grant NIOSH-Publication Physiology
• ISSN:
  0006-2952
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Maine ; Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  26
• Issue:
  22
• NIOSHTIC Number:
  nn:00111764
• Citation:
  Biochem Pharmacol 1977; 26(22):2151-2155
• Contact Point Address:
  Physiology Harvard University 665 Huntington Ave Boston, Mass 02115
• CAS Registry Number:
  Acrylamide (CAS RN 79-06-1)
• Federal Fiscal Year:
  1977
• NORA Priority Area:
  Other Occupational Concerns ; Grants Other
• Performing Organization:
  Harvard University, Boston, Massachusetts
• Peer Reviewed:
  True
• Start Date:
  19710101
• Source Full Name:
  Biochemical Pharmacology
• End Date:
  19810430
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:283aa938c8a30e98b5ae05647cac08f7e15995b17ba3078da2f16ea44e19e88cd408a55e7c68d485bef8f0a9f59f5dd187e56a6b2cab5fec4aee01e35c2663a7
• Download URL:
  https://stacks.cdc.gov/view/cdc/184396/cdc_184396_DS1.pdf
• File Type:
  [PDF - 578.58 KB ]