Toxic Mechanisms of Inhaled Methyl Methacrylate Vapor

Details

• Personal Author:
  Tansy MF
• Description:
  The toxic effects of inhaled methyl-methacrylate (80626) (MMA) vapor in Sprague-Dawley-rats were studied. Animals inhaled 116 parts per million (ppm) of MMA 8 hours daily, 5 days a week, for 45 or 90 days. Body weight, daily food intake, fecal fat content, intestinal absorption, plasma lipid concentration, and tissue fat concentrations were measured at various intervals. Ninety day inhalation of MMA affected tissue weight, blood chemistry, metabolic behavior, and hepatic and ciliary function in rats, but did not depress body weight or epididymal or popliteal fat pad weight. MMA also produced gastrointestinal motor inhibition and histological evidence of liver damage. The LC50 for rats inhaling MMA was 7093ppm; death was caused by respiratory failure. The author concludes that MMA inhibits gastrointestinal contractility and hepatic metabolism. He notes that preliminary research with other volatile acrylates such as ethyl-acrylate and butyl-acrylate shows that these compounds have effects similar to those for MMA. [Description provided by NIOSH]
• Subjects:
  Biochemistry Energy Metabolism Histology Laboratories Occupational Health Safety
• Keywords:
  Grants-other Laboratory-animals Metabolism NIOSH-Grant Physiology Reaction-rates
• Series:
  Grant Final Reports
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-4
• NIOSHTIC Number:
  nn:00112356
• NTIS Accession Number:
  PB88-252663
• Citation:
  Department of Physiology and Biophysics, Temple University School of Dentistry, Philadelphia, Pennsylvania 1979 Feb; :1-4
• Contact Point Address:
  Physiology and Biophysics Temple University 3223 N Broad Street Philadelphia, PA 19140
• CAS Registry Number:
  2-Propenoic acid, 2-methyl-, methyl ester (CAS RN 80-62-6)
• Federal Fiscal Year:
  1979
• NORA Priority Area:
  Other Occupational Concerns ; Grants Other
• Performing Organization:
  Temple University, Philadelphia, Pennsylvania
• Peer Reviewed:
  False
• Start Date:
  19740501
• Source Full Name:
  Department of Physiology and Biophysics, Temple University School of Dentistry, Philadelphia, Pennsylvania
• End Date:
  19810331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3640adb3b0a05bba06bed79b4770abc4e59611a0827ac9a3d982293d41f2b88fe6b0f5eb698853d9129e0d50ce345909d200294eb5a873e5559e64d2326b3f74
• Download URL:
  https://stacks.cdc.gov/view/cdc/217703/cdc_217703_DS1.pdf
• File Type:
  [PDF - 3.04 MB ]