Biochemical effects of 1,1-dichloroethylene in rats: dissociation of its hepatotoxicity from a lipoperoxidative mechanism.

Details

• Personal Author:
  Jaeger RJ ; Murphy SD ; Trabulus MJ
• Description:
  The dose response and time course of hepatic injury following oral administration of 1,1-dichloroethylene (75354) are studied in rats by measuring hepatic glucose-6-phosphatase, serum alanine-alpha- ketoglutarate transaminase, hepatic-triglyceride, and pentobarbital sleeping time, and comparison to carbon-tetrachloride (56235) in terms of the ability to stimulate lipoperoxidation in-vitro and in- vivo. Results indicate that 1,1-dichloroethylene produces some of the same liver and serum enzyme changes associated with the hepatotoxicity of carbon-tetrachloride, but the mechanisms are dissimilar. [Description provided by NIOSH]
• Subjects:
  Biochemistry Digestive System Energy Metabolism Liver Occupational Health Safety Toxicology
• Keywords:
  Grants-other Hepatotoxins Liver-function Metabolism NIOSH-Grant NIOSH-Publication Pharmacology
• ISSN:
  0041-008X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  457-467
• Volume:
  24
• Issue:
  3
• NIOSHTIC Number:
  nn:00023570
• Citation:
  Toxicol Appl Pharmacol 1973 Mar; 24(3):457-467
• Contact Point Address:
  Physiology Harvard University 665 Huntington Ave Boston, Mass 02115
• CAS Registry Number:
  Carbon tetrachloride (CAS RN 56-23-5) ; Vinylidene chloride (CAS RN 75-35-4)
• Federal Fiscal Year:
  1973
• NORA Priority Area:
  Other Occupational Concerns ; Grants Other
• Performing Organization:
  Harvard University, Boston, Massachusetts
• Peer Reviewed:
  True
• Start Date:
  19710101
• Source Full Name:
  Toxicology and Applied Pharmacology
• End Date:
  19810430
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:592abe525fff81cfe399825c8cc1fb8b7e37c20f33858341af91e9acc818f06ef8daf0124274a37d58ca6f72ac22d9baa72a70ff5605423a819032fbd4058787
• Download URL:
  https://stacks.cdc.gov/view/cdc/183857/cdc_183857_DS1.pdf
• File Type:
  [PDF - 782.03 KB ]