Fibrogenic potential of slags used as substitutes for sand in abrasive blasting operations.

Details

• Personal Author:
  Donaldson, Harry M. ; Kommineni C ; Mackay GR ; Stettler, Lloyd E.
• Description:
  The fibrogenic potentials of coal-slag (68476960) and copper slag (67711982) used as substitutes for silica (7631869) sand in abrasive blasting operations were assessed. Rats were administered 20 milligrams (mg) of coal or copper grit slag, airborne copper slag, or standard quartz, by intralobar instillation. All surviving animals were autopsied after 10 months. Pulmonary fibrosis was seen in the coal-slag treated animals but not in the copper slag treated group. Granulomas were seen in the lungs from all treatment groups. The authors note that chronic inhalation experiments using animal models are necessary to assess the biological response to silica sand substitutes until data becomes available on responses of workers exposed to slags. [Description provided by NIOSH]
• Subjects:
  Aluminum Silicates Carcinogens Fibrosis Laboratories Metals, Heavy Minerals Occupational Health Particulate Matter Respiratory Tract Diseases Safety
• Keywords:
  Carcinogenesis Fibrogenicity Fibrous-bodies Heavy-metals Laboratory-animals NIOSH-Author Pulmonary-system-disorders Silicates
• ISSN:
  0002-8894
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  41
• Issue:
  11
• NIOSHTIC Number:
  nn:00104403
• Citation:
  Am Ind Hyg Assoc J 1980 Nov; 41(11):836-842
• CAS Registry Number:
  Coal-combustion slags (CAS RN 68476-96-0) ; Silica (CAS RN 7631-86-9) ; Slags, dore furnace (CAS RN 67711-98-2)
• Federal Fiscal Year:
  1981
• Peer Reviewed:
  True
• Source Full Name:
  American Industrial Hygiene Association Journal
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f9f2d7d2a76d3a771aa5c38ec68f9c95895f6b97591a0732d0720a4d05dbcd91cb00727677616878f7931e1faa9309f951d3b5d2d697377b2c116f18020a1dfa
• Download URL:
  https://stacks.cdc.gov/view/cdc/184371/cdc_184371_DS1.pdf
• File Type:
  [PDF - 799.38 KB ]