Reactive Oxygen Species and Silica-Induced Carcinogenesis

Details

• Personal Author:
  Castranova, Vincent ; Chen F ; Ding M ; Shi X ; Vallyathan V
• Description:
  Epidemiological and pathological studies have established that occupational exposure to crytalline silica leads to the development of pulmonary fibrosis (1,2). Increasing evidence from epidemiological and animal studies has also implicated crystalline silica as a potential carcinogen (3,4) (e.g., inhalation of silica has been shown to be carcinogenic in rats) (5-9). Intrapleural administration of crytalline silica in rats leads to the induction of localized malignant histiocytic lymphomas. Epidemiological studies also show that there appears to be an increased lung cancer risk in many, but not all, human subjects with silicosis (4,9). Based on current evidence obtained from studies on laboratory animals and epidemiological studies on humans, the International Agency for Reseearch on Cancer has classified crytalline silica as a human class I carcinogen (9). [Description provided by NIOSH]
• Subjects:
  Aluminum Silicates Carcinogens Epidemiology Fibrosis Lung Diseases Occupational Exposure Occupational Health Pathology Respiratory Tract Diseases Safety
• Keywords:
  Carcinogenesis Occupational Exposure Pulmonary System Disorders Silicates
• Publisher:
  CRC Press
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  203-224
• Volume:
  1
• NIOSHTIC Number:
  nn:20021446
• Citation:
  Environmental stressors in health and disease. Fuchs J, Packer L, eds. Boca Raton, FL: CRC Press, 2001 Jul; :203-224
• Editor(s):
  Fuchs J; Packer L
• Federal Fiscal Year:
  2001
• NORA Priority Area:
  Other Occupational Concerns ; Pulmonary System Disorders
• Peer Reviewed:
  False
• Source Full Name:
  Environmental stressors in health and disease
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e929a9dc79ecc3f0340957db355529c1d59eb34fa9c2abaaa921167850bc9e7a87d0d4e662e709e6be5c877419da72474a53482f594520ef318239747f35d1b5
• Download URL:
  https://stacks.cdc.gov/view/cdc/198760/cdc_198760_DS1.pdf
• File Type:
  [PDF - 602.25 KB ]