The neurology and neuropathology of the occupational neuropathies.

Details

• Personal Author:
  Schaumburg HH ; Spencer PS
• Description:
  The relevant basic anatomy and pathology of peripheral nerve are reviewed and correlated with the clinico-pathological phenomena observed in some occupational neuropathies. The majority of occupational neuropathies are caused by neurotoxins in the work area and the clinico-pathological profiles indicate that they conform to the axonal type. Occupational neuropathies occurring subsequent to exposure to n-hexane (110543), acrylamide (79061), methyl-n-butyl- ketone, (591786) and 2,5-hexanedione (110134) are discussed in some detail. The most prominent feature in the clinical neurology of the hexacarbon neuropathies is the insidious onset of the progressive distal weakness and sensory loss in the lower extremities. Also mentioned are neuropathies induced by carbon-disulfide (75150) and o- cresyl-phosphate (78308). [Description provided by NIOSH]
• Subjects:
  Nervous System Diseases Occupational Exposure Occupational Health Pathology Safety Solvents Toxicology
• Keywords:
  Grants-other Industrial-chemicals JOCMA7 Nervous-system-disorders NIOSH-Grant NIOSH-Publication Occupational-exposure Organic-solvents
• ISSN:
  0096-1736
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  18
• Issue:
  11
• NIOSHTIC Number:
  nn:00070857
• Citation:
  J Occup Med 1976 Nov; 18(11):739-742
• Contact Point Address:
  Pathology Albert Einstein Coll of Med 1300 Morris Park Avenue Bronx, N Y 10461
• CAS Registry Number:
  2,5-Hexanedione (CAS RN 110-13-4) ; 2-Hexanone (CAS RN 591-78-6) ; Acrylamide (CAS RN 79-06-1) ; Carbon disulfide (CAS RN 75-15-0) ; Hexane (CAS RN 110-54-3) ; o-Cresyl phosphate (CAS RN 78-30-8)
• Federal Fiscal Year:
  1977
• NORA Priority Area:
  Grants Other
• Performing Organization:
  Yeshiva University, New York, New York
• Peer Reviewed:
  True
• Start Date:
  19751101
• Source Full Name:
  Journal of Occupational Medicine
• End Date:
  19850331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6b2e4bd2635b7786b568eda3f731553e4c44871b285500fa0aaa5ae9609253b40b3fea23b76ecfe0e013d091e897c86d7a19897c4d5ca231053f70f7a0c49f28
• Download URL:
  https://stacks.cdc.gov/view/cdc/184164/cdc_184164_DS1.pdf
• File Type:
  [PDF - 385.71 KB ]