Neurotoxic properties of certain aliphatic hexacarbons.

Details

• Personal Author:
  Schaumburg HH ; Spencer PS
• Description:
  The importance of chronic testing of potentially neurotoxic compounds in experimental animals is emphasized to describe the range of hexacarbon compounds identified as neurotoxic agents, and to characterize and illustrate the pathological basis for the onset of the nervous system disease. The compounds tested are: n-hexane (110543), methyl-n-butylketone (591786), 2,5-hexanedione (110134), 2,5-hexanediol (2935446), 2,4-hexanedione, 2,3-hexanedione (3848246), and 1,6-hexanediol. Results show that animals chronically intoxicated with these neurotoxic hexacarbons slowly develop a peripheral neuropathy and display concurrent distal nerve fiber degeneration in the peripheral nervous system, and in ascending and descending spinal cord tracts of the central nervous system. [Description provided by NIOSH]
• Subjects:
  Hazardous Substances Hydrocarbons Nervous System Nervous System Diseases Occupational Health Safety Solvents
• Keywords:
  Aliphatic-hydrocarbons Chronic-toxicity Grants-other Nervous-system-disorders Neurotoxicity NIOSH-Grant NIOSH-Publication Organic-solvents
• ISSN:
  0035-9157
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  37-39
• Volume:
  70
• Issue:
  1
• NIOSHTIC Number:
  nn:00071427
• Citation:
  Proc R Soc Med 1977 Jan; 70(1):37-39
• Contact Point Address:
  Pathology Albert Einstein Coll of Med 1300 Morris Park Avenue Bronx, N Y 10461
• CAS Registry Number:
  2,3-Hexanedione (CAS RN 3848-24-6) ; 2,5-Hexanediol (CAS RN 2935-44-6) ; 2,5-Hexanedione (CAS RN 110-13-4) ; 2-Hexanone (CAS RN 591-78-6) ; Hexane (CAS RN 110-54-3)
• Federal Fiscal Year:
  1977
• NORA Priority Area:
  Other Occupational Concerns ; Grants Other
• Performing Organization:
  Yeshiva University, New York, New York
• Peer Reviewed:
  True
• Start Date:
  19751101
• Source Full Name:
  Proceedings of the Royal Society of Medicine
• End Date:
  19850331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3f640ef1a5efae08130c98fa7bf1b9d0611550c25494e5818261e4febb7339e393bc372464634e128abc5f59a06cadc8df2ab9ecde128417a18603c4481d4e5d
• Download URL:
  https://stacks.cdc.gov/view/cdc/184184/cdc_184184_DS1.pdf
• File Type:
  [PDF - 662.72 KB ]