Nervous system degeneration produced by acrylamide monomer.

Details

• Personal Author:
  Schaumburg HH ; Spencer PS
• Description:
  Review of the neurotoxic property of acrylamide. One major problem discussed is the protection of factory workers engaged in the manufacture of acrylamide. A sensitive test of neurologic function in these individuals, touch sensation, based on the experimental observation of the exquisite vulnerability of Pecinian corpuscles in acrylamide intoxicated cats, is presently under consideration. The second area for concern is the exposure of the populace to minute amounts of neurotoxic acrylamide monomer which contaminate acrylamide polymers currently deployed in the environment. Federal restrictions on the maximum permitted exposure to acrylamide, based on a largely clincial study of acrylamide neurotoxicity conducted ten years ago, may require a re-evaluation in the light of recent advances which have pinpointed the initial sites of nerve fiber degeneration. [Description provided by NIOSH]
• Subjects:
  Amides Hazardous Substances Nervous System Nervous System Diseases Occupational Health Plastics Safety
• Keywords:
  Nervous-system-disorders Neurotoxicity NIOSH-Grant NIOSH-Publication Toxic-substances
• ISSN:
  0091-6765
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  129-133
• Volume:
  11
• NIOSHTIC Number:
  nn:00048432
• Citation:
  Environ Health Perspect 1975 Jun; 11:129-133
• Contact Point Address:
  Pathology Albert Einstein Coll of Med 1300 Morris Park Avenue Bronx, N Y 10461
• CAS Registry Number:
  Acrylamide (CAS RN 79-06-1)
• Federal Fiscal Year:
  1975
• Performing Organization:
  Yeshiva University, New York, New York
• Peer Reviewed:
  True
• Start Date:
  19751101
• Source Full Name:
  Environmental Health Perspectives
• End Date:
  19850331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5eef307b4e51deb57e90047f03c53cba0ae68c78f723715b60c0e89367816d94c5cd4f6d30f0f03e0c226f55f7449e8c8ec4a1b2b19fdb52816d4c80add4f347
• Download URL:
  https://stacks.cdc.gov/view/cdc/184047/cdc_184047_DS1.pdf
• File Type:
  [PDF - 836.06 KB ]