The neuropathology of industrial neuropathies.

Details

• Personal Author:
  Schaumburg HH ; Spencer PS
• Description:
  Acrylamide (79061) (10 milligrams per kilogram per day) and four chemically and biologically related straight chain hexacarbons, n- hexane (110543) (500ppm), methyl-n-butyl-ketone (300 milligrams per kilogram per day, subcutaneously), 2,5-hexanedione (110134) and 2,5- hexanediol (2935446) (as 0.5 percent drinking solutions) were used to study the pattern and spatial-temporal distribution of nervous system degeneration in the cat and rat. The results of the studies showed that all compounds produced a typical peripheral neuropathy which is characterized clinically by slowly-developing hindlimb weakness. Unlike the clinical expression of the disease, pathological changes are not confined to the peripheral nervous system, but occur concurrently in both the central and peripheral nervous system as axonal degeneration of the dying back type. It is suggested that the favored hypothesis to account for the dying-back process, progressive impairment of neuronal perikaryal metabolism, is not likely to be entirely responsible for distal axonal degeneration. (Grant No. R01-OH-00535) [Description provided by NIOSH]
• Subjects:
  Amides Butanones Hazardous Substances Nervous System Nervous System Diseases Occupational Health Safety Solvents
• Keywords:
  NIOSH-Grant; Neurotoxic-effects; Nervous-system-disorders; Neurotoxicity; Toxic-substances; Amides; Organic-solvents; Ketones; Solvents
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Proceedings
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-9
• NIOSHTIC Number:
  nn:00071487
• Citation:
  International Symposium on Neurotoxicology, May 16-19 1976. 1976 May; :1-9
• Contact Point Address:
  Pathology Albert Einstein Coll of Med 1300 Morris Park Avenue Bronx, N Y 10461
• CAS Registry Number:
  2,5-Hexanediol (CAS RN 2935-44-6) ; 2,5-Hexanedione (CAS RN 110-13-4) ; Acrylamide (CAS RN 79-06-1) ; Hexane (CAS RN 110-54-3)
• Federal Fiscal Year:
  1976
• NORA Priority Area:
  Neurotoxic Disorders ; Neurotoxic Effects
• Performing Organization:
  Yeshiva University, New York, New York
• Peer Reviewed:
  False
• Start Date:
  19751101
• Source Full Name:
  International Symposium on Neurotoxicology, May 16-19 1976
• End Date:
  19850331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/242073/cdc_242073_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]