Behavioral effects of acrylamide in the mouse.

Details

• Personal Author:
  Evans HL ; Teal JJ
• Description:
  The effects of acrylamide (79061) on a test of appetite behavior, milk licking, was compared with standard measures of toxicity using both time effect and dose response functions. In addition, the suitability of using the mouse to evaluate behavioral toxicity and to characterize the behavioral effects of acrylamide was determined. Two strains of mice, CD-1-mice and C57BL/6J-mice, were injected intraperitoneally five times weekly with either saline, 20, 60 or 100 milligrams per kilogram (mg/kg) of acrylamide. Body weight loss, mortality, hindlimb grip strength, and locomotor activity were evaluated in parallel with milk licking. After 5 weeks of dosing with 20mg/kg, decreased hindlimb grip strength was observed but there was no effect on milk licking or body weight. Within three weeks of administration of the 60mg/kg dose, slight loss of body weight was evident as was neuropathy and a 50 percent mortality rate. In contrast, by day two of treatment with this dose there was a highly significant increase in episodic milk licking which persisted throughout the dosing period. Administration of 100mg/kg subchronically, but not acutely, resulted in weight loss and severe neuropathy within 3 days and a 100 percent mortality rate within 2 weeks. The authors conclude that compared to standard measures of toxicity, milk licking proved to be a more sensitive indicator of acrylamide toxicity, increases in milk licking were evident even in severely intoxicated mice and preceded other signs of toxicity, and that the magnitude of the daily dose rather than the cumulative dose is a better predictor of the onset of various toxic effects. They suggest that the mouse is a valid animal model for studies in behavioral toxicology. [Description provided by NIOSH]
• Subjects:
  Amides Laboratories Mortality Nervous System Nervous System Diseases Occupational Health Safety Toxicology
• Keywords:
  Analytical Methods Behavioral Tests Laboratory Animals Models Mortality Rates Nervous System Disorders
• ISSN:
  0041-008X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  470-480
• Volume:
  63
• Issue:
  3
• NIOSHTIC Number:
  nn:00122706
• Citation:
  Toxicol Appl Pharmacol 1982 May; 63(3):470-480
• Contact Point Address:
  Dr. H. L. Evans, Environmental Medicine, New York University, 550 First Ave., New York, N.Y. 10016
• CAS Registry Number:
  Acrylamide (CAS RN 79-06-1)
• Federal Fiscal Year:
  1982
• Peer Reviewed:
  True
• Source Full Name:
  Toxicology and Applied Pharmacology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e1e6994d3c26463e98fc14fce8d1172a05e155d281f4384583907d8fe00d3c4802a2eadb33d7895be761da2146d386e4d03fcb68072052a799e0f8adb52154ad
• Download URL:
  https://stacks.cdc.gov/view/cdc/184546/cdc_184546_DS1.pdf
• File Type:
  [PDF - 917.54 KB ]