Emergence of Oseltamivir-Resistant Pandemic (H1N1) 2009 Virus within 48 Hours

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Inoue, Masafumi ; Barkham, Timothy ; Leo, Yee-Sin ; Chan, Kwai-Peng ; Chow, Angela ; Wong, Christopher W. ; Lee, Raphael Tze-Chuen ; Maurer-Stroh, Sebastian ; Lin, Raymond ; Lin, Cui
• Description:
  An oseltamivir-resistant influenza A pandemic (H1N1) 2009 virus evolved and emerged from zero to 52% of detectable virus within 48 hours of a patient's exposure to oseltamivir. Phylogenetic analysis and data gathered by pyrosequencing and cloning directly on clinical samples suggest that the mutant emerged de novo.
• Subjects:
  Adult Antiviral Agents Drug Resistance, Viral Evolution, Molecular Female Humans Influenza, Human Influenza A Virus, H1N1 Subtype Mutation Oseltamivir Pandemics Phylogeny Sequence Analysis, Dna Time Factors

  More +
• Source:
  Emerg Infect Dis. 16(10):1633-1636.
• Document Type:
  Journal Article
• Place as Subject:
  Singapore
• Volume:
  16
• Issue:
  10
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:fcb505f168ab4c67f5128c760c6636bdf5b07936ebe73b370946394e50f78653
• Download URL:
  https://stacks.cdc.gov/view/cdc/18351/cdc_18351_DS1.pdf
• File Type:
  [PDF - 384.84 KB ]