Hypersensitivity pneumonitis antigens activate alveolar macrophanges in vitro.

Details

• Personal Author:
  Milanowski J
• Description:
  The gaseous phase cultures of alveolar macrophages (AMs) of guinea pigs were exposed to the saline extracts of the dust-borne bacteria Micropolyspora faeni (syn. Faenia rectivirgula) and Erwinia herbicola (syn. Enterobacter agglomerans) which have been added at the concentration of 1 ug/ml to culture medium with or without complement. The effects of exposure on superoxide anion (o2-) production by AMs were assessed by the lucigenin-dependent chemiluminescence method. Both extracts caused significant (p < 0.01) increase in o2- generation by AMs, as assessed by the 161-254 percent enhancement of chemiluminescence release comparing to control values. The presence of complement augmented the production o02-, which reached a peak at 3 hours after initial exposure. The possible significance of the generation of oxygen radicals in pathogenesis of the diseases due to exposure to agricultural dusts loaded with bacterial antigens is discussed.
• Subjects:
  • Accidents, Occupational
  • Carcinogens
  • Occupational Health
  • Personal Protective Equipment
  • Safety
• Keywords:
  • Pneumonitis
  • Lung disease
  • Dusts
  • Dust exposure
  • Animals
  • Laboratory animals
  • Lung
  • Exposure levels
  • Risk factors
  • Bacteria
  More +
• Document Type:
  Text
• Editor:
  Myers ML ; Herrick RF ; Olenchock SA ; Myers JR ; Parker, John E. ; Hard DL ; Wilson K
• Genre:
  Abstract
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  570
• NIOSHTIC Number:
  nn:20056030
• Citation:
  Papers and Proceedings of the Surgeon General's Conference on Agricultural Safety and Health (FarmSafe 2000). Myers ML, Herrick RF, Olenchock SA, Myers JR, Parker, John E., Hard DL, Wilson K, eds. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 92-105, 1992 Sep; :570
• CAS Registry Number:
  • Oxygen (CAS RN 7782-44-7)
• Editor(s):
  Myers ML ; Herrick RF ; Olenchock SA ; Myers JR ; Parker, John E. ; Hard DL ; Wilson K
• Federal Fiscal Year:
  1992
• Peer Reviewed:
  False
• Source Full Name:
  Papers and Proceedings of the Surgeon General's Conference on Agricultural Safety and Health (FarmSafe 2000), April 30-May 3, 1991, Des Moines, Iowa
• Download URL:
  https://stacks.cdc.gov/view/cdc/181772/cdc_181772_DS1.pdf
• File Type:
  [PDF - 52.23 KB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ea90e61f16eec22629423fffc9a299e56a35e7620cea1f5e3351d8a2d872637bcbf78d7e32f0b65a79b31159098fb9ef009b08c9ed28e143eaa9c2262ddb0249