Hypersensitivity pneumonitis (HP) in rats caused by Aspergillus umbrosus and Thermoactinomyces vulgaris.

Details

• Personal Author:
  Husman K ; Kotimas M ; Lewis, Dick ; Manninen A ; Olenchock S ; Sorenson, William ; Terho E ; Vallyathan V
• Description:
  HP is an allergic lung disease in the terminal bronchioles, interstitium and alveoli resulting from repeated exposure to inhaled organic dusts. Thermophilic actinomycetes and fungal spores have been implicated as causes of HP in man. To evaluate the inflammatory potential of the two microorganisms, we exposed rats (Sprague-Dawley, VAF) to extracts of Aspergillus umbrosus (AU) and Thennoactinomyces vulgaris (TV) six times by intratracheal injection. We made a pathologic evaluation of the changes in the lungs and in the cellular influx in bronchoalveolar lavage fluids (BALF) of exposed and control animals. Initial installations of AU and TV caused an intense inflammatory reaction in and around respiratory bronchioles and blood vessels. The cellular infiltrate (CI) predominantly was lymphocytes, but the number of macrophages was also increased. Lymphatoid granulomas were seen as well as thickening of alveolar walls with type II cell hyperplasia. The number of the total cells in BALF increased dramatically, two-and-onehalf to fivefold, compared to the controls. Differential estimates of CI showed 71 percent lymphocytes and 27 percent macrophages. Eight and 28 days after the final exposure, the lung appeared normal. These results indicate that these agents can cause an intense pulmonary inflammation, and that the inflammation subsides rapidly when the exposure ends, leaving no apparent permanent pulmonary injury.
• Subjects:
  • Accidents, Occupational
  • Biochemistry
  • Energy Metabolism
  • Hazardous Substances
  • Methylnitrosourea
  • Mutagens
  • Occupational Health
  • Safety
• Keywords:
  • Pneumonitis
  • Lung disease
  • Dusts
  • Dust exposure
  • Fungi
  • Microorganisms
  • Animals
  • Laboratory animals
  • Pathology
  • Lung
  More +
• Document Type:
  Text
• Editor:
  Myers ML ; Herrick RF ; Olenchock SA ; Myers JR ; Parker, John E. ; Hard DL ; Wilson K
• Genre:
  Abstract
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  569
• NIOSHTIC Number:
  nn:20056027
• Citation:
  Papers and Proceedings of the Surgeon General's Conference on Agricultural Safety and Health (FarmSafe 2000). Myers ML, Herrick RF, Olenchock SA, Myers JR, Parker, John E., Hard DL, Wilson K, eds. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 92-105, 1992 Sep; :569
• Editor(s):
  Myers ML ; Herrick RF ; Olenchock SA ; Myers JR ; Parker, John E. ; Hard DL ; Wilson K
• Federal Fiscal Year:
  1992
• Peer Reviewed:
  False
• Source Full Name:
  Papers and Proceedings of the Surgeon General's Conference on Agricultural Safety and Health (FarmSafe 2000), April 30-May 3, 1991, Des Moines, Iowa
• Download URL:
  https://stacks.cdc.gov/view/cdc/181771/cdc_181771_DS1.pdf
• File Type:
  [PDF - 60.48 KB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4b233814b58af2017ae3d2a483ff47af882099c0f2cd09e50d3bd85908aa0cd701789f91e0981c18019729577e9912e53f91e62fecb7fa17858e0d9ddbf651b0