Reassortment of Human Rotavirus Gene Segments into G11 Rotavirus Strains

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Matthijnssens, Jelle ; Rahman, Mustafizur ; Ciarlet, Max ; Zeller, Mark ; Heylen, Elisabeth ; Nakagomi, Toyoko ; Uchida, Ryuichi ; Hassan, Zahid ; Azim, Tasnim ; Nakagomi, Osamu ; Van Ranst, Marc
• Description:
  G11 rotaviruses are believed to be of porcine origin. However, a limited number of G11 rotaviruses have been recently isolated from humans in combination with P[25], P[8], P[6], and P[4]. To investigate the evolutionary relationships of these strains, we analyzed the complete genomes of 2 human G11P[25] strains, 2 human G11P[8] strains, and 3 porcine reference strains. Most of the 11 gene segments of these 7 strains belonged to genotype 1 (Wa-like). However, phylogenetic clustering patterns suggested that an unknown G11P[25] strain with a new I12 VP6 genotype was transmitted to the human population, in which it acquired human genotype 1 gene segments through reassortment, resulting in a human G11P[8] rotavirus strain with an entire human Wa-genogroup backbone. This Wa-like backbone is believed to have caused the worldwide spread of human G9 and G12 rotaviruses. G11 human rotavirus strains should be monitored because they may also become major human pathogens.
• Subjects:
  Animals G11 Genes, Viral Genome Genotype Humans Phylogeny Reassortant Viruses Reassortment Research Reverse Transcriptase Polymerase Chain Reaction Rotavirus Rotavirus Infections Sequence Analysis, DNA Swine Swine Diseases Viruses Wa Genogroup

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• Source:
  Emerg Infect Dis. 16(4):625-630.
• Document Type:
  Journal Article
• Volume:
  16
• Issue:
  4
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:1d16163f55e5cea43258fc95710cceb740d5da037903d7098418230f9f7ad853
• Download URL:
  https://stacks.cdc.gov/view/cdc/18128/cdc_18128_DS1.pdf
• File Type:
  [PDF - 203.10 KB ]