An update from hospital-based surveillance for rotavirus gastroenteritis among young children in Bangladesh, July 2012 to June 2017

Details

• Alternative Title:
  Vaccine
• Personal Author:
  Satter, Syed M ; Aliabadi, Negar ; Gastañaduy, Paul A. ; Haque, Warda ; Mamun, Abdullah ; Flora, Meerjady S ; Zaman, K. ; Rahman, Mustafizur ; Heffelfinger, James D. ; Luby, Stephen P. ; Gurley, Emily S. ; Parashar, Umesh D.
  More +
• Description:
  Introduction: ; In preparation for the introduction of a rotavirus vaccine into the routine immunization program of Bangladesh in 2018, we report data and highlight evolving genotypes from five years of active hospital-based rotavirus surveillance which began in July 2012. ; Methods: ; We enrolled and collected fresh stool from every fourth child < 5 years admitted with acute gastroenteritis (AGE) at 8 participating surveillance hospitals. Rotavirus infections were detected by enzyme immune assay. Twenty-five percent of rotavirus isolates were genotyped using reverse transcription polymerase chain reaction. ; Results: ; We found that 64% (4832/7562) of children < 5 years of age admitted with AGE had evidence of rotavirus infection. The majority (57%) of patients with rotavirus infection were <12 months of age. The most common strains were G1P8 (43%), G12P8 (15%) and G9P8 (9%); 11% of children had mixed infection.G3P8, which has not been reported in Bangladesh since 2001, was documented for the first time in our surveillance system. ; Conclusions: ; The high burden of rotavirus-associated hospitalizations highlights the potential value of rotavirus vaccination in Bangladesh. Continued surveillance is important for monitoring the impact of vaccination as well as monitoring evolving genotypes.
• Keywords:
  • Bangladesh
  • Rotavirus
  • Hospital based surveillance
  • Rotavirus vaccination
  • Bangladesh
  • Child, Preschool
  • Diarrhea
  • Feces
  • Female
  • Gastroenteritis
  More +
• Source:
  Vaccine. 36(51):7811-7815
• Pubmed ID:
  29793894
• Pubmed Central ID:
  PMC9169511
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/ ; U51 GH001209/GH/CGH CDC HHSUnited States/
• Volume:
  36
• Issue:
  51
• Download URL:
  https://stacks.cdc.gov/view/cdc/118092/cdc_118092_DS1.pdf
• File Type:
  [PDF - 435.94 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:b28ceb822abdc006a1cfb976950660b729dce86d07e8bd2a310c3f83f34e9e0c