Associations between Mycobacterium tuberculosis Strains and Phenotypes

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Brown, Timothy ; Nikolayevskyy, Vladyslav ; Velji, Preya ; Drobniewski, Francis
• Description:
  To inform development of tuberculosis (TB) control strategies, we characterized a total of 2,261 Mycobacterium tuberculosis complex isolates by using multiple phenotypic and molecular markers, including polymorphisms in repetitive sequences (spoligotyping and variable-number tandem repeats [VNTRs]) and large sequence and single-nucleotide polymorphisms. The Beijing family was strongly associated with multidrug resistance (p = 0.0001), and VNTR allelic variants showed strong associations with spoligotyping families: >or=5 copies at exact tandem repeat (ETR) A, >or=2 at mycobacterial interspersed repetitive unit 24, and >or=3 at ETR-B associated with the East African-Indian and M. bovis strains. All M. tuberculosis isolates were differentiated into 4 major lineages, and a maximum parsimony tree was constructed suggesting a more complex phylogeny for M. africanum. These findings can be used as a model of pathogen global diversity.
• Subjects:
  Bacteria Bacterial Typing Techniques Drug Resistance Emigrants And Immigrants Female Genetic Polymorphisms Genotype Humans London Male Microbial Evolution Minisatellite Repeats Mycobacterium Tuberculosis Phenotype Phenotypes Phylogeny Research Tuberculosis, Multidrug-Resistant Tuberculosis And Other Mycobacteria

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• Source:
  Emerg Infect Dis. 16(2):272-280.
• Document Type:
  Journal Article
• Volume:
  16
• Issue:
  2
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:e5f7d07195acdfa39eda692c97ae31e0edd552798f7328193cb3891a6f412f16
• Download URL:
  https://stacks.cdc.gov/view/cdc/18021/cdc_18021_DS1.pdf
• File Type:
  [PDF - 340.73 KB ]