Roofing asphalts, pitch and UVL carcinogenesis.

Details

• Personal Author:
  Menzies KT ; Thayer PS ; Thuna PC
• Description:
  The tumorigenicity to mouse skin of volatile components of roofing asphalts and coal tar pitches was investigated. Male CD-1 and C3H/H3J-mice were exposed to 25 milligrams per application of asphalt volatiles or 1.5 to 4.2 milligrams per application of pitch preparations. Treatment was twice weekly for an 18 month period with two temperatures of generation of volatile materials and exposure or lack of exposure to simulated sunlight. The C3H strain of mice was more sensitive to the tumorigenic activity, while simulated sunlight had an inhibitory effect on the rate of appearance of tumors but not on the final tumor incidence. The higher temperature of preparation of the asphalt volatiles resulted in greater tumorigenic activity. The authors conclude that the asphalt volatiles were almost as tumorigenic and carcinogenic to C3H- mice as the pitch volatiles.
• Subjects:
  Accidents, Occupational Agriculture Diagnosis Health Care Facilities Workforce And Services Insecticides Occupational Exposure Occupational Health Poisoning Safety
• Keywords:
  Asphalt-cements; Carcinogenesis Contract-210-78-0035 Laboratory-animals NIOSH-Contract Skin-cancer Tumorigenesis
• Document Type:
  Text
• Funding:
  Contract;
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-116
• NIOSHTIC Number:
  nn:00122945
• Citation:
  NIOSH 1981 Nov; :1-116
• Federal Fiscal Year:
  1982
• Peer Reviewed:
  False
• Source Full Name:
  U.S. Department of Health and Human Services, NIOSH, Cincinnati, Ohio, 116 pages, 35 references
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:33475acb3c8649e1d3100b0d3c78d60ee88c975d7b83518389434210ebf5dab4410720aba619b4780158c85e7b3587224cf4f4878ca80e8a41add4a0e4ee00c7
• Download URL:
  https://stacks.cdc.gov/view/cdc/179445/cdc_179445_DS1.pdf
• File Type:
  [PDF - 4.23 MB ]