Susceptibilities of Nonhuman Primates to Chronic Wasting Disease

Race, Brent; Meade-White, Kimberly D.; Miller, Michael W.; Barbian, Kent D.; Rubenstein, Richard; LaFauci, Giuseppe; Cervenakova, Larisa; Favara, Cynthia; Gardner, Donald; Long, Dan; Parnell, Michael; Striebel, James; Priola, Suzette A.; Ward, Anne; Williams, Elizabeth S.; Race, Richard; Chesebro, Bruce

i

Susceptibilities of Nonhuman Primates to Chronic Wasting Disease

Supporting Files Public Domain

Sep 2009
By Race, Brent ; Meade-White, Kimberly D. ; Miller, Michael W.

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Race, Brent ; Meade-White, Kimberly D. ; Miller, Michael W. ; Barbian, Kent D. ; Rubenstein, Richard ; LaFauci, Giuseppe ; Cervenakova, Larisa ; Favara, Cynthia ; Gardner, Donald ; Long, Dan ; Parnell, Michael ; Striebel, James ; Priola, Suzette A. ; Ward, Anne ; Williams, Elizabeth S. ; Race, Richard ; Chesebro, Bruce
Description:

Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy, or prion disease, that affects deer, elk, and moose. Human susceptibility to CWD remains unproven despite likely exposure to CWD-infected cervids. We used 2 nonhuman primate species, cynomolgus macaques and squirrel monkeys, as human models for CWD susceptibility. CWD was inoculated into these 2 species by intracerebral and oral routes. After intracerebral inoculation of squirrel monkeys, 7 of 8 CWD isolates induced a clinical wasting syndrome within 33-53 months. The monkeys' brains showed spongiform encephalopathy and protease-resistant prion protein (PrPres) diagnostic of prion disease. After oral exposure, 2 squirrel monkeys had PrPres in brain, spleen, and lymph nodes at 69 months postinfection. In contrast, cynomolgus macaques have not shown evidence of clinical disease as of 70 months postinfection. Thus, these 2 species differed in susceptibility to CWD. Because humans are evolutionarily closer to macaques than to squirrel monkeys, they may also be resistant to CWD.
Subjects:
Source:

Emerg Infect Dis. 15(9):1366-1376.
Document Type:

Journal Article
Volume:

15
Issue:

9
Download URL:

https://stacks.cdc.gov/view/cdc/17861/cdc_17861_DS1.pdf
File Type:

[PDF - 775.62 KB]
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:6a77020f09d3c9c68c0d040dd57c8d71df1da8b107ee4a69c8c6f4fc9c2c0203

ON THIS PAGE

Details Supporting Files

Was this page helpful?

Found an issue?

Send us an email at:

publishinghd@cdc.gov

CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.

As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.