CTX-M β-Lactamases in Escherichia coli from Community-acquired Urinary Tract Infections, Cambodia

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Ruppé, Etienne ; Hem, Sopheak ; Lath, Sovannarith ; Gautier, Valérie ; Ariey, Frédéric ; Sarthou, Jean-Louis ; Monchy, Didier ; Arlet, Guillaume
• Description:
  Despite the recent global spread of CTX-M beta-lactamases in Escherichia coli isolates from community-acquired urinary tract infections (CA-UTIs), their dissemination has been little studied in developing countries. In a 2-year prospective study, we documented the prevalence of extended-spectrum beta-lactamases (ESBLs) in E. coli that were responsible for CA-UTIs in Phnom-Penh, Cambodia. Ninety-three E. coli strains were included. We observed a high prevalence of resistance to amoxicillin (88.2% of strains), cotrimoxazole (75.3%), ciprofloxacin (67.7%), gentamicin (42.5%), and third-generation cephalosporins (37.7%). A total of 34 strains carried ESBLs, all of which were CTX-M type. CTX-M carriage was associated with resistance to fluoroquinolones and aminoglycosides. U using repetitive extragenic palindromic-PCR, we identified 4 clusters containing 9, 8, 3, and 2 strains. The prevalence of CTX-M beta-lactamases has reached a critical level in Cambodia, which highlights the need for study of their spread in developing countries.
• Subjects:
  • Research
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aminoglycosides
  • Anti-Bacterial Agents
  • Child
  • Child, Preschool
  • Community-Acquired Infections
  More +
• Source:
  Emerg Infect Dis. 15(5):741-748.
• Document Type:
  Journal Article
• Place as Subject:
  Cambodia
• Location:
  Asia
• Volume:
  15
• Issue:
  5
• Download URL:
  https://stacks.cdc.gov/view/cdc/17657/cdc_17657_DS1.pdf
• File Type:
  [PDF - 453.43 KB]
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:a35282e73915e0d8e1a6e50ee7924ea96225a9da81552d6c90ed80f7927d5b8f