CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.
As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.
i
Rise and Persistence of Global M1T1 Clone of Streptococcus pyogenes
-
Oct 2008
-
-
Source: Emerg Infect Dis. 14(10):1511-1517
Details:
-
Alternative Title:Emerg Infect Dis
-
Personal Author:
-
Description:The resurgence of severe invasive group A streptococcal infections in the 1980s is a typical example of the reemergence of an infectious disease. We found that this resurgence is a consequence of the diversification of particular strains of the bacteria. Among these strains is a highly virulent subclone of serotype M1T1 that has exhibited unusual epidemiologic features and virulence, unlike all other streptococcal strains. This clonal strain, commonly isolated from both noninvasive and invasive infection cases, is most frequently associated with severe invasive diseases. Because of its unusual prevalence, global spread, and increased virulence, we investigated the unique features that likely confer its unusual properties. In doing so, we found that the increased virulence of this clonal strain can be attributed to its diversification through phage mobilization and its ability to sense and adapt to different host environments; accordingly, the fittest members of this diverse bacterial community are selected to survive and invade host tissue.
-
Subjects:
-
Source:
-
Pubmed ID:18826812
-
Pubmed Central ID:PMC2609857
-
Document Type:
-
Volume:14
-
Issue:10
-
Collection(s):
-
Main Document Checksum:
-
Download URL:
-
File Type: