Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Song, Daesub ; Kang, Bokyu ; Lee, Chulseung ; Jung, Kwonil ; Ha, Gunwoo ; ... More +
Song, Daesub ; Kang, Bokyu ; Lee, Chulseung ; Jung, Kwonil ; Ha, Gunwoo ; Kang, Dongseok ; Park, Seongjun ; Park, Bongkyun ; Oh, Jinsik Less -
Description:
In South Korea, where avian influenza virus subtypes H3N2, H5N1, H6N1, and H9N2 circulate or have been detected, 3 genetically similar canine influenza virus (H3N2) strains of avian origin (A/canine/Korea/01/2007, A/canine/Korea/02/2007, and A/canine/Korea/03/2007) were isolated from dogs exhibiting severe respiratory disease. To determine whether the novel canine influenza virus of avian origin was transmitted among dogs, we experimentally infected beagles with this influenza virus (H3N2) isolate. The beagles shed virus through nasal excretion, seroconverted, and became ill with severe necrotizing tracheobronchitis and bronchioalveolitis with accompanying clinical signs (e.g., high fever). Consistent with histologic observation of lung lesions, large amounts of avian influenza virus binding receptor (SAalpha 2,3-gal) were identified in canine tracheal, bronchial, and bronchiolar epithelial cells, which suggests potential for direct transmission of avian influenza virus (H3N2) from poultry to dogs. Our data provide evidence that dogs may play a role in interspecies transmission and spread of influenza virus.
Subject:
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Animals
Avian
Dog
Dog Diseases
Dogs
H3N2
Influenza A Virus, H3N2 Subtype
Influenza In Birds
Influenza Virus
Orthomyxoviridae Infections
Poultry
Receptors, Cell Surface
Research
Species Specificity

Source:
Emerg Infect Dis. 14(5):741-746.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:8f130df2599646fb0646cb8acec3200efc23951a95e7bfcd928015d9ef97513b
File Type:

Supporting Files

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