Integrating Host Genomics with Surveillance for Invasive Bacterial Diseases

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Crawford, Dana C. ; Zimmer, Shanta M. ; Morin, Craig A. ; Messonnier, Nancy E. ; Lynfield, Ruth ; Yi, Qian ; Shephard, Cynthia ; Wong, Michelle ; Rieder, Mark J. ; Livingston, Robert J. ; Nickerson, Deborah A. ; Whitney, Cynthia G. ; Lingappa, Jairam
• Description:
  We tested the feasibility of linking Active Bacterial Core surveillance, a prospective, population-based surveillance system for invasive bacterial disease, to a newborn dried blood spot (nDBS) repository. Using nDBS specimens, we resequenced CD46, putative host gene receptor for Neisseria meningitidis, and identified variants associated with susceptibility to this disease.
• Subjects:
  Active Bacterial Core Surveillance Antigens, CD46 Blood Spots Case-Control Studies CD46 Child, Preschool Dispatch Feasibility Studies Genetic Predisposition To Disease Host Gene Humans Infant Infant, Newborn Meningitis, Bacterial Neisseria Meningitidis Neonatal Screening Polymorphism, Single Nucleotide Population Surveillance Retrospective Studies

  More +
• Source:
  Emerg Infect Dis. 14(7):1138-1140.
• Document Type:
  Journal Article
• Volume:
  14
• Issue:
  7
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:48685d8f3afc2e47b9006efa71cc132202583fb3490335afd6902819e35c8235
• Download URL:
  https://stacks.cdc.gov/view/cdc/17062/cdc_17062_DS1.pdf
• File Type:
  [PDF - 139.82 KB ]