Integrating Host Genomics with Surveillance for Invasive Bacterial Diseases
Published Date:Jul 2008
Source:Emerg Infect Dis. 14(7):1138-1140.
Keywords:Active Bacterial Core Surveillance
Genetic Predisposition To Disease
Polymorphism, Single Nucleotide
Description:We tested the feasibility of linking Active Bacterial Core surveillance, a prospective, population-based surveillance system for invasive bacterial disease, to a newborn dried blood spot (nDBS) repository. Using nDBS specimens, we resequenced CD46, putative host gene receptor for Neisseria meningitidis, and identified variants associated with susceptibility to this disease.
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