Epidemiology of Bacterial Meningitis in the North American Arctic, 2000–2010

Details

• Alternative Title:
  J Infect
• Personal Author:
  Gounder, Prabhu P. ; Zulz, Tammy ; Desai, Shalini ; Stenz, Flemming ; Rudolph, Karen ; Tsang, Raymond ; Tyrrell, Gregory J. ; Bruce, Michael G.
• Description:
  Objective ; To determine the incidence of meningitis caused by Haemophilus influenzae, Neisseria meningitidis, and Streptococcus pneumoniae in the North American Arctic during 2000–2010. ; Methods ; Surveillance data were obtained from the International Circumpolar Surveillance network. We defined a case of bacterial meningitis caused by H. influenzae, N. meningitidis, or S. pneumoniae as a culture-positive isolate obtained from a normally sterile site in a resident with a meningitis diagnosis. ; Results ; The annual incidence/100,000 persons for meningitis caused by H. influenzae, N. meningitidis, and S. pneumoniae among all North American Arctic residents was: 0.6, 0.5, and 1.5, respectively; the meningitis incidence among indigenous persons in Alaska and Canada (indigenous status not recorded in Greenland) for those three bacteria was: 2.1, 0.8, and 2.4, respectively. The percentage of pneumococcal isolates belonging to a 7-valent pneumococcal conjugate vaccine serotype declined from 2000–2004 to 2005–2010 (31% to 2%, p-value <0.01). During 2005–2010, serotype a caused 55% of H. influenzae meningitis and serogroup B caused 86% of meningococcal meningitis. ; Conclusions ; Compared with all North American Arctic residents, indigenous people suffer disproportionately from bacterial meningitis. Arctic residents could benefit from the development of a H. influenzae serotype a vaccine and implementation of a meningococcal serogroup B vaccine.
• Subjects:
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Arctic Regions
  • Child
  • Child, Preschool
  • Epidemiological Monitoring
  • Female
  • Haemophilus influenzae
  More +
• Keywords:
  • bacterial meningitis
  • epidemiology
  • Haemophilus influenzae
  • Neisseria meningitidis
  • Streptococcus pneumoniae
• Source:
  J Infect. 71(2):179-187
• Pubmed ID:
  25864638
• Pubmed Central ID:
  PMC4560175
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHSUnited States/
• Volume:
  71
• Issue:
  2
• Download URL:
  https://stacks.cdc.gov/view/cdc/34080/cdc_34080_DS1.pdf
• File Type:
  [PDF - 554.26 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:7852874ff0df13672cccee78a834c8b2c989eed4cba0c1ee97c9da2b425935389ee4bbeabccb0babbd4a453969c8e22b9c0a2c465e74a5083f6f1132076e0a4d