Factors associated with infant sex and preterm birth status for selected birth defects from the National Birth Defects Prevention Study, 1997–2011

Details

• Alternative Title:
  Birth Defects Res
• Personal Author:
  Williford, Eva M. ; Yang, Wei ; Howley, Meredith M. ; Ma, Chen ; Collins, Ronnie T. ; Weber, Kari A. ; Heinke, Dominique ; Petersen, Julie M. ; Agopian, A. J. ; Archer, Natalie P. ; Olshan, Andrew F. ; Williams, Lindsay A. ; Browne, Marilyn L. ; Shaw, Gary M.
• Corporate Authors:
  National Birth Defects Prevention Study
• Description:
  Background:
  
  Birth defects and preterm birth co-occur, with some overlapping risk factors. Many birth defects and preterm births tend to have a male preponderance. We explored potential risk factors impacting sex and preterm (<37 weeks of gestation) birth differences among infants with selected birth defects delivered from 1997 to 2011 using data from the National Birth Defects Prevention Study (NBDPS).
  
  Methods:
  
  The NBDPS was a large multisite, population-based case–control study. Using random forests, we identified important predictors of male preterm, female preterm, and male term, each compared with female term births for each birth defect. Using logistic regression, we estimated odds ratios for associations between important predictors and sex-preterm birth status by birth defect.
  
  Results:
  
  We examined 11,379 infants with nine specific birth defects. The top 10 most important predictors of sex-preterm birth status from the random forests varied greatly across the birth defects and sex-preterm comparisons within a given defect group, with several being novel factors. However, one consistency was that short interpregnancy interval was associated with sex-preterm birth status for many of the studied birth defects. Although obesity has been identified as a risk factor for preterm birth and birth defects in other research, it was not associated with sex-preterm birth status for any of the examined defects.
  
  Conclusions:
  
  We confirmed expected associations for sex-preterm birth status differences and found new potential risk factors for further exploration among the studied birth defects.
  
  
• Subjects:
  Case-Control Studies Female Humans Infant Infant, Newborn Logistic Models Male Premature Birth
• Keywords:
  Birth Defects Preterm Birth Random Forests Sex
• Source:
  Birth Defects Res. 116(1):e2294
• Pubmed ID:
  38155422
• Pubmed Central ID:
  PMC11561737
• Document Type:
  Journal Article
• Funding:
  CDP 13-003/HX/HSRD VAUnited States/ ; FOA #DD09-001/CC/CDC HHSUnited States/ ; U01 DD001304/DD/NCBDD CDC HHSUnited States/ ; U01 DD001224/DD/NCBDD CDC HHSUnited States/ ; FOA #DD13-003/CC/CDC HHSUnited States/ ; U01 DD001227/DD/NCBDD CDC HHSUnited States/ ; PA #96043/CC/CDC HHSUnited States/ ; U01 DD001032/DD/NCBDD CDC HHSUnited States/ ; PA #02081/CC/CDC HHSUnited States/ ; EP-D-18-001/EPA/EPAUnited States/ ; U01 DD001300/DD/NCBDD CDC HHSUnited States/ ; NOFO #DD18-001/CC/CDC HHSUnited States/ ; U01 DD001037/DD/NCBDD CDC HHSUnited States/
• Volume:
  116
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:c2eb8044a6c03faaad6519ec1e95f58a0e75811f6b3cd94a383405fc952e96ac873acad7d7767ffeef24c89580f6eee1dba444100f0b3996c93624bd792a0707
• Download URL:
  https://stacks.cdc.gov/view/cdc/169994/cdc_169994_DS1.pdf
• File Type:
  [PDF - 263.16 KB ]