Non-A Hepatitis B Virus Genotypes in Antenatal Clinics, United Kingdom

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Dervisevic, Samir ; Ijaz, Samreen ; Chaudry, Shahneila ; Tedder, Richard S.
• Description:
  In the United Kingdom, the National Screening Programme for identification of hepatitits B virus (HBV) infection in pregnant women uses HBV e antigen (HBeAg) and antibody to HBeAg (anti-HBe) as markers of infectivity to determine use of immunoglobulin for hepatitis B. Serum samples from 114 HBV-infected women were analyzed. Viral loads correlated with HBeAg/anti-HBe status and viral genotypes. Among 95 mothers whose serum contained anti-HBe, viral loads ranged between undetectable and 8.6 x 10(6) IU/mL (median 228 IU/mL). Ten (10.5%) of these mothers had plasma viral loads >10(4) IU/mL; 6 were infected with genotype E and one each with genotypes A, B, C, and D. All viruses had precore stop codon or basal core promoter mutations. Preponderance of genotypes other than A among antenatal mothers in the United Kingdom reflects increasing globalization and trends in immigration. HBeAg serostatus is no longer sufficiently accurate for inferring potential infectivity of pregnant HBV carriers.
• Subjects:
  • Research
  • Hepatitis B virus
  • hepatitis B virus DNA
  • hepatitis B virus e antigen
  • antibody to hepatitis B virus e protein
  • precore mutations
  • basal core promoter
  • HBV genotypes
  • pregnancy
  • research
  More +
• Source:
  Emerg Infect Dis. 13(11):1689-1693.
• Document Type:
  Journal Article
• Volume:
  13
• Issue:
  11
• Download URL:
  https://stacks.cdc.gov/view/cdc/16853/cdc_16853_DS1.pdf
• File Type:
  [PDF - 239.96 KB]
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:96d2d3551a39e05090d7435e619310b1ae5c52bf5bab1c49f72eb9099aee9ae9