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Hepatitis B Virus (HBV) Load Response to 2 Antiviral Regimens, Tenofovir/Lamivudine and Lamivudine, in HIV/ HBV-Coinfected Pregnant Women in Guangxi, China: The Tenofovir in Pregnancy (TiP) Study
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12 01 2016
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Source: J Infect Dis. 214(11):1695-1699
[PDF-217.77 KB]
Details:
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Alternative Title:J Infect Dis
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Personal Author:
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Description:Background.
There is limited information on antiviral therapy for hepatitis B virus (HBV) infection among pregnant women coinfected with human immunodeficiency virus (HIV) and HBV.
Methods.
A phase 2 randomized, controlled trial of a regimen containing tenofovir (TDF)/lamivudine (3TC) and a regimen containing 3TC in HIV/HBV-coinfected pregnant women in China. The HBV virological response was compared in study arms.
Results.
The median decline in the HBV DNA level was 2.60 log10 copies/mL in the TDF/3TC arm and 2.24 log10 copies/mL in the 3TC arm (P = .41). All women achieved HBV DNA levels of <6 log10 copies/mL at delivery.
Conclusions.
Initiation of either regimen led to achievement of HBV DNA levels below the threshold associated with perinatal HBV transmission.
Clinical Trials Registration.
NCT01125696.
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Source:
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Pubmed ID:27658693
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Pubmed Central ID:PMC11264234
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Funding:
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Volume:214
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Issue:11
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