Hepatitis B Virus (HBV) Load Response to 2 Antiviral Regimens, Tenofovir/Lamivudine and Lamivudine, in HIV/ HBV-Coinfected Pregnant Women in Guangxi, China: The Tenofovir in Pregnancy (TiP) Study

Details

• Alternative Title:
  J Infect Dis
• Personal Author:
  Wang, Liming ; Wiener, Jeffrey ; Bulterys, Marc ; Wei, Xiaoyu ; Chen, Lili ; Liu, Wei ; Liang, Shujia ; Shepard, Colin ; Wang, Linhong ; Wang, Ailing ; Zhang, Fujie ; Kourtis, Athena P.
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• Description:
  Background. ; There is limited information on antiviral therapy for hepatitis B virus (HBV) infection among pregnant women coinfected with human immunodeficiency virus (HIV) and HBV. ; Methods. ; A phase 2 randomized, controlled trial of a regimen containing tenofovir (TDF)/lamivudine (3TC) and a regimen containing 3TC in HIV/HBV-coinfected pregnant women in China. The HBV virological response was compared in study arms. ; Results. ; The median decline in the HBV DNA level was 2.60 log10 copies/mL in the TDF/3TC arm and 2.24 log10 copies/mL in the 3TC arm (P = .41). All women achieved HBV DNA levels of <6 log10 copies/mL at delivery. ; Conclusions. ; Initiation of either regimen led to achievement of HBV DNA levels below the threshold associated with perinatal HBV transmission. ; Clinical Trials Registration. ; NCT01125696.
• Subjects:
  • Adult
  • Antiviral Agents
  • China
  • Coinfection
  • Female
  • HIV Infections
  • Hepatitis B
  • Hepatitis B virus
  • Humans
  • Lamivudine
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• Keywords:
  • tenofovir
  • HIV/HBV coinfection
  • pregnancy
  • HBV suppression
  • lamivudine
  • HBV DNV viral load
• Source:
  J Infect Dis. 214(11):1695-1699
• Pubmed ID:
  27658693
• Pubmed Central ID:
  PMC11264234
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  214
• Issue:
  11
• Download URL:
  https://stacks.cdc.gov/view/cdc/159352/cdc_159352_DS1.pdf
• File Type:
  [PDF - 217.77 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:305b49a508375ba8b8e724657419694a01a4be84a9356ed528b60ffe77bbcc123debc0f6b666805230c9d2810370b0298ea8d4b9750132400d13c3362e4ffbe0