Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Bartels, Mette Damkjær ; Boye, Kit ; Larsen, Anders Rhod ; Skov, Robert ; Westh, Henrik
Bartels, Mette Damkjær ; Boye, Kit ; Larsen, Anders Rhod ; Skov, Robert ; Westh, Henrik Less -
Description:
In Copenhagen, methicillin-resistant Staphylococcus aureus (MRSA) accounted for <15 isolates per year during 1980-2002. However, since 2003 an epidemic increase has been observed, with 33 MRSA cases in 2003 and 110 in 2004. We analyzed these 143 cases epidemiologically and characterized isolates by pulsed-field gel electrophoresis, Staphylococcus protein A (spa) typing, multilocus sequence typing, staphylococcal chromosome cassette (SCC) mec typing, and detection of Panton-Valentine leukocidin (PVL) genes. Seventy-one percent of cases were community-onset MRSA (CO-MRSA); of these, 36% had no identified risk factors. We identified 29 spa types (t) and 16 sequence types (STs) belonging to 8 clonal complexes and 3 ST singletons. The most common clonal types were t024/ST8-IV, t019/ST30-IV, t044/ST80-IV, and t008/ST8-IV (USA300). A total of 86% of isolates harbored SCCmec IV, and 44% had PVL. Skin and soft tissue infections dominated. CO-MRSA with diverse genetic backgrounds is rapidly emerging in a low MRSA prevalence area.
Subject:
[+]
Communicable Diseases, Emerging
Community-Acquired Infections
Cross Infection
Evolution, Molecular
Genetic Variation
Humans
Methicillin Resistance
Phylogeny
Research
Staphylococcal Infections

Source:
Emerg Infect Dis. 13(10):1533-1540.
Document Type:
Journal Article
Place as Subject:
Denmark
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:3c2e1247788678e3bc4dd410f6e01a31d12434ac9adac09a7d21157cc88388ff
File Type:

Supporting Files

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  	07-0503-F.jpg	jpeg
  	07-0503_appF-s1.gif	gif
  	07-0503_appT-s2.pdf	pdf
  	07-0503_finalR.nxml	txt
  	license.txt	txt

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