Levels of Abnormal Prion Protein in Deer and Elk with Chronic Wasting Disease

Race, Brent L.; Meade-White, Kimberly D.; Ward, Anne; Jewell, Jean; Miller, Michael W.; Williams, Elizabeth S.; Chesebro, Bruce; Race, Richard E.

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Levels of Abnormal Prion Protein in Deer and Elk with Chronic Wasting Disease

Published Date:

Jun 2007

Source:

Emerg Infect Dis. 13(6):824-829.

[PDF - 360.05 KB]

Details:

Personal Authors:

Race, Brent L. ; Meade-White, Kimberly D. ; Ward, Anne ; Jewell, Jean ; Miller, Michael W. ; ... More ▼

Keywords:

[+]

Description:

Chronic wasting disease (CWD) of deer and elk is a widespread health concern because its potential for crossspecies transmission is undetermined. CWD prevalence in wild elk is much lower than its prevalence in wild deer, and whether CWD-infected deer and elk differ in ability to infect other species is unknown. Because lymphoid tissues are important in the pathogenesis of some transmissible spongiform encephalopathies such as sheep scrapie, we investigated whether CWD-affected elk and deer differ in distribution or quantity of disease-associated prion protein (PrPres) in lymphoid tissues. Immunoblot quantification of PrPres from tonsil and retropharyngeal lymph nodes showed much higher levels of PrPres in deer than in elk. This difference correlated with the natural prevalence of CWD in these species and suggested that CWD-infected deer may be more likely than elk to transmit the disease to other cervids and have a greater potential to transmit CWD to noncervids.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Supporting Files:

07-0186-F1.gif	image/gif
07-0186-F1.jpg	image/jpeg
07-0186-F2.gif	image/gif
07-0186-F2.jpg	image/jpeg
07-0186-F3.gif	image/gif
07-0186-F3.jpg	image/jpeg
07-0186-F4.gif	image/gif
07-0186-F4.jpg	image/jpeg
07-0186_finalR.nxml	text/plain
license.txt	text/plain

No Related Documents.

You May Also Like:

Human Prion Disease and Relative Risk Associated with Chronic Wasting Disease

Personal Author:

Pape, W. John; Forster, Jeri E.; Anderson, C. Alan; Bosque, Patrick; Miller, Michael W.;

Corporate Author:

Samantha MaWhinney

Published:

Oct 2006

Source:

Emerg Infect Dis. 12(10):1527-1535.

Description:

The transmission of the prion disease bovine spongiform encephalopathy (BSE) to humans raises concern about chronic wasting disease (CWD), a prion disease of deer and elk. In 7 Colorado counties with high CWD prevalence, 75% of state hunting licenses...

File Type:

[PDF - 278.65 KB]
Chronic Wasting Disease Prions in Elk Antler Velvet

Personal Author:

Angers, Rachel C.; Seward, Tanya S.; Napier, Dana; Green, Michael; Hoover, Edward; Spraker, Terry; O’Rourke, Katherine; Balachandran, Aru; Telling, Glenn C.;

Published:

May 2009

Source:

Emerg Infect Dis. 15(5):696-703.

Description:

Chronic wasting disease (CWD) is a contagious, fatal prion disease of deer and elk that continues to emerge in new locations. To explore the means by which prions are transmitted with high efficiency among cervids, we examined prion infectivity in th...

File Type:

[PDF - 2.39 MB]
Chronic Wasting Disease in Free-Ranging Wisconsin White-Tailed Deer

Personal Author:

Joly, Damien O.; Ribic, Christine A.; Langenberg, Julie A.; Beheler, Kerry; Batha, Carl A.; Dhuey, Brian J.; Rolley, Robert E.; Bartelt, Gerald; van Deelen, Timothy R.; Samuel, Michael D.;

Published:

May 2003

Source:

Emerg Infect Dis. 9(5):599-601.

Description:

Three White-tailed Deer shot within 5 km during the 2001 hunting season in Wisconsin tested positive for chronic wasting disease, a prion disease of cervids. Subsequent sampling within 18 km showed a 3% prevalence (n=476). This discovery represents a...

File Type:

[PDF - 241.56 KB]
Atypical Scrapie Prions from Sheep and Lack of Disease in Transgenic Mice Overexpressing Human Prion Protein

Personal Author:

Wadsworth, Jonathan D.F.; Joiner, Susan; Linehan, Jacqueline M.; Balkema-Buschmann, Anne; Spiropoulos, John; Simmons, Marion M.; Griffiths, Peter C.; Groschup, Martin H.; Hope, James; Brandner, Sebastian; Asante, Emmanuel A.; Collinge, John;

Published:

Nov 2013

Source:

Emerg Infect Dis. 19(11):1731-1739.

Description:

Public and animal health controls to limit human exposure to animal prions are focused on bovine spongiform encephalopathy (BSE), but other prion strains in ruminants may also have zoonotic potential. One example is atypical/Nor98 scrapie, which evad...

File Type:

[PDF - 727.19 KB]
Horizontal Transmission of Chronic Wasting Disease in Reindeer

Personal Author:

Moore, S. Jo; Kunkle, Robert; Greenlee, M. Heather West; Nicholson, Eric; Richt, Jürgen; Hamir, Amir; Waters, W. Ray; Greenlee, Justin;

Published:

Dec 2016

Source:

Emerg Infect Dis. 22(12):2142-2145.

Description:

We challenged reindeer by the intracranial route with the agent of chronic wasting disease sourced from white-tailed deer, mule deer, or elk and tested for horizontal transmission to naive reindeer. Reindeer were susceptible to chronic wasting diseas...

File Type:

[PDF - 1.87 MB]