Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Race, Brent L. ; Meade-White, Kimberly D. ; Ward, Anne ; Jewell, Jean ; Miller, Michael W. ; ... More +
Race, Brent L. ; Meade-White, Kimberly D. ; Ward, Anne ; Jewell, Jean ; Miller, Michael W. ; Williams, Elizabeth S. ; Chesebro, Bruce ; Race, Richard E. Less -
Description:
Chronic wasting disease (CWD) of deer and elk is a widespread health concern because its potential for crossspecies transmission is undetermined. CWD prevalence in wild elk is much lower than its prevalence in wild deer, and whether CWD-infected deer and elk differ in ability to infect other species is unknown. Because lymphoid tissues are important in the pathogenesis of some transmissible spongiform encephalopathies such as sheep scrapie, we investigated whether CWD-affected elk and deer differ in distribution or quantity of disease-associated prion protein (PrPres) in lymphoid tissues. Immunoblot quantification of PrPres from tonsil and retropharyngeal lymph nodes showed much higher levels of PrPres in deer than in elk. This difference correlated with the natural prevalence of CWD in these species and suggested that CWD-infected deer may be more likely than elk to transmit the disease to other cervids and have a greater potential to transmit CWD to noncervids.
Subject:
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Animals Animals, Domestic Brain Deer Lymph Nodes Palatine Tonsil Prions Research Spleen Wasting Disease, Chronic
Source:
Emerg Infect Dis. 13(6):824-829.
Document Type:
Journal Article
Place as Subject:
Colorado ; Montana
Colorado ; Montana Less -
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:11c98cb309d876a895dcae4c4d5f879bbc7657ee1db33b815f390386a08ee0f8
Download URL:
https://stacks.cdc.gov/view/cdc/16726/cdc_16726_DS1.pdf
File Type:

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