Virus Detection and Monitoring of Viral Load in Crimean-Congo Hemorrhagic Fever Virus Patients

Wölfel, Roman; Paweska, Janusz T.; Petersen, Nadine; Grobbelaar, Antoinette A.; Leman, Patricia A.; Hewson, Roger; Georges-Courbot, Marie-Claude; Papa, Anna; Günther, Stephan; Drosten, Christian

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Virus Detection and Monitoring of Viral Load in Crimean-Congo Hemorrhagic Fever Virus Patients

Published Date:

Jul 2007

Source:

Emerg Infect Dis. 13(7):1097-1100.

[PDF - 309.43 KB]

Details:

Personal Authors:

Wölfel, Roman ; Paweska, Janusz T. ; Petersen, Nadine ; Grobbelaar, Antoinette A. ; Leman, Patricia A. ; ... More ▼

Keywords:

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Description:

We developed a real-time reverse transcription--PCR that detected 1,164 copies/mL of Crimean-Congo hemorrhagic fever virus per milliliter of serum at 95% probability (probit analysis) and was 100% concordant with nested PCR on 63 samples from 31 patients with confirmed infection. Infected patients who died appeared to have higher viral loads; low viral loads correlated with IgG detection.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Supporting Files:

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