Virus Detection and Monitoring of Viral Load in Crimean-Congo Hemorrhagic Fever Virus Patients

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Wölfel, Roman ; Paweska, Janusz T. ; Petersen, Nadine ; Grobbelaar, Antoinette A. ; Leman, Patricia A. ; Hewson, Roger ; Georges-Courbot, Marie-Claude ; Papa, Anna ; Günther, Stephan ; Drosten, Christian
• Description:
  We developed a real-time reverse transcription--PCR that detected 1,164 copies/mL of Crimean-Congo hemorrhagic fever virus per milliliter of serum at 95% probability (probit analysis) and was 100% concordant with nested PCR on 63 samples from 31 patients with confirmed infection. Infected patients who died appeared to have higher viral loads; low viral loads correlated with IgG detection.
• Subjects:
  5′-nuclease Assay Crimean-Congo Hemorrhagic Fever Virus Dispatch Genetic Variation Hemorrhagic Fever, Crimean Hemorrhagic Fever Virus, Crimean-Congo Humans Phylogeny Reproducibility Of Results Reverse Transcriptase Polymerase Chain Reaction RT-PCR Sensitivity And Specificity Species Specificity Viral Load

  More +
• Source:
  Emerg Infect Dis. 13(7):1097-1100.
• Document Type:
  Journal Article
• Volume:
  13
• Issue:
  7
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:e8eaaec53195f66e7abb8323ac1dc4e07ae63019e586223379e378b040a282ac
• Download URL:
  https://stacks.cdc.gov/view/cdc/16688/cdc_16688_DS1.pdf
• File Type:
  [PDF - 309.43 KB ]