Gastroenteritis and Transmission of Helicobacter pylori Infection in Households1

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Perry, Sharon ; Sanchez, Maria de la Luz ; Yang, Shufang ; Haggerty, Thomas D. ; Hurst, Philip ; Perez-Perez, Guillermo ; Parsonnet, Julie
• Description:
  The mode of transmission of Helicobacter pylori infection is poorly characterized. In northern California, 2,752 household members were tested for H. pylori infection in serum or stool at a baseline visit and 3 months later. Among 1,752 person considered uninfected at baseline, 30 new infections (7 definite, 7 probable, and 16 possible) occurred, for an annual incidence of 7% overall and 21% in children <2 years of age. Exposure to an infected household member with gastroenteritis was associated with a 4.8-fold (95% confidence interval [CI] 1.4-17.1) increased risk for definite or probable new infection, with vomiting a greater risk factor (adjusted odds ratio [AOR] 6.3, CI 1.6-24.5) than diarrhea only (AOR 3.0, p = 0.65). Of probable or definite new infections, 75% were attributable to exposure to an infected person with gastroenteritis. Exposure to an H. pylori-infected person with gastroenteritis, particularly vomiting, markedly increased risk for new infection.
• Subjects:
  Adolescent Adult Age Factors Child Child, Preschool Children Family Characteristics Female Gastroenteritis Helicobacter Infections Helicobacter Pylori Humans Incidence Infant Male Prospective Studies Research Serology Stool Antigen

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• Source:
  Emerg Infect Dis. 12(11):1701-1708.
• Document Type:
  Journal Article
• Volume:
  12
• Issue:
  11
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:88e129bd5df338fd9c1b0e59e26fbe9579fb46a12c809e7581cf646d747ac991
• Download URL:
  https://stacks.cdc.gov/view/cdc/16218/cdc_16218_DS1.pdf
• File Type:
  [PDF - 130.08 KB ]