Preexisting Heterotypic Ligand-blocking Antibody Does Not Protect Against Genogroup II Norovirus Episodes in Young Children

Details

• Alternative Title:
  J Pediatric Infect Dis Soc
• Personal Author:
  Becker-Dreps, Sylvia ; Brewer-Jensen, Paul D. ; González, Fredman ; Reyes, Yaoska ; Mallory, Michael L. ; Gutiérrez, Lester ; Vielot, Nadja A. ; Diez-Valcarce, Marta ; Vinjé, Jan ; Baric, Ralph S. ; Lindesmith, Lisa C. ; Bucardo, Filemon
• Description:
  A birth cohort design was used to understand whether heterotypic ligand-blocking norovirus antibodies provide cross-protection within the GII genogroup. We found that almost one-half of children who experienced a norovirus GII episode had preexisting antibodies heterotypic to the infecting genotype; therefore, these antibodies did not provide cross-protection.
• Subjects:
  Caliciviridae Infections Child Child, Preschool Feces Gastroenteritis Genotype Humans Infant Ligands Norovirus
• Keywords:
  Children Diarrhea Gastroenteritis Immunity Nicaragua Norovirus
• Source:
  J Pediatric Infect Dis Soc. 11(10):459-462
• Pubmed ID:
  35849117
• Pubmed Central ID:
  PMC9595053
• Document Type:
  Journal Article
• Funding:
  K24 AI141744/AI/NIAID NIH HHSUnited States/ ; D43TW010923/TW/FIC NIH HHSUnited States/ ; R01 AI127845/AI/NIAID NIH HHSUnited States/ ; R01 AI148260/AI/NIAID NIH HHSUnited States/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/ ; D43 TW010923/TW/FIC NIH HHSUnited States/
• Volume:
  11
• Issue:
  10
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:b157a77129f3ebbdd9468c06778410790a3ad784c30499550b3edb33356e0eef
• Download URL:
  https://stacks.cdc.gov/view/cdc/121969/cdc_121969_DS1.pdf
• File Type:
  [PDF - 324.64 KB ]