Meningococcal Disease in South Africa, 1999–2002

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Coulson, Garry B. ; von Gottberg, Anne ; du Plessis, Mignon ; Smith, Anthony M. ; de Gouveia, Linda ; Klugman, Keith P. ; in South Africa, Meningeal Disease Surveillance
• Corporate Authors:
  for the Group for Enteric ; Respiratory ; GERMS-SA
• Description:
  We describe the epidemiology of invasive meningococcal disease in South Africa from August 1999 through July 2002, as reported to a laboratory-based surveillance system. Neisseria meningitidis isolates were further characterized. In total, 854 cases of laboratory-confirmed disease were reported, with an annual incidence rate of 0.64/100,000 population. Incidence was highest in infants < 1 year of age. Serogroup B caused 41% of cases; serogroup A, 23%; serogroup Y, 21%; serogroup C, 8%; and serogroup W135, 5%. Serogroup B was the predominant serogroup in Western Cape Province, and disease rates remained stable. Serogroup A was most prevalent in Gauteng Province and increased over the 3 years. On pulsed-field gel electrophoresis analysis, serogroup A strains showed clonality, and serogroup B demonstrated considerable diversity. Selected isolates of serogroup A belonged to sequence type (ST)-1 (subgroup I/II) complex, serogroup B to ST-32/electrophoretic type (ET)-5 complex, and serogroup W135 to ST-11/ET-37 complex.
• Subjects:
  Humans Meningococcal Infections Molecular Epidemiology Neisseria Meningitidis Serotyping
• Source:
  Emerg Infect Dis. 13(2):273-281.
• Document Type:
  Journal Article
• Place as Subject:
  South Africa
• Volume:
  13
• Issue:
  2
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:6f36c2be7ea52da19d03fc59c27384bbcde8edf625e6ff56e0214cde51a672d5
• Download URL:
  https://stacks.cdc.gov/view/cdc/16170/cdc_16170_DS1.pdf
• File Type:
  [PDF - 251.98 KB ]