Antimicrobial Susceptibility Survey of Invasive Neisseria meningitidis, United States 2012–2016

Details

• Alternative Title:
  J Infect Dis
• Personal Author:
  Potts, Caelin C. ; Rodriguez-Rivera, Lorraine D. ; Retchless, Adam C. ; Hu, Fang ; Marjuki, Henju ; Blain, Amy E. ; McNamara, Lucy A. ; Wang, Xin
• Description:
  Background.
  
  Historically, antimicrobial resistance has been rare in US invasive meningococcal disease cases.
  
  Methods.
  
  Meningococcal isolates (n = 695) were collected through population-based surveillance, 2012–2016, and national surveillance, 2015–2016. Antimicrobial susceptibility was assessed by broth microdilution. Resistance mechanisms were characterized using whole-genome sequencing.
  
  Results.
  
  All isolates were susceptible to 6 antibiotics (cefotaxime, ceftriaxone, meropenem, rifampin, minocycline, and azithromycin). Approximately 25% were penicillin or ampicillin intermediate; among these, 79% contained mosaic penA gene mutations. Less than 1% of isolates were penicillin, ampicillin, ciprofloxacin, or levofloxacin resistant.
  
  Conclusions.
  
  Penicillin- and ampicillin-intermediate isolates were common, but resistance to clinically relevant antibiotics remained rare.
  
  
• Subjects:
  Ampicillin Anti-Bacterial Agents Ceftriaxone Ciprofloxacin Humans Meningococcal Infections Microbial Sensitivity Tests Neisseria Meningitidis Penicillins United States
• Keywords:
  Antibiotic Resistance Antimicrobial Susceptibility Ciprofloxacin Invasive Meningococcal Disease PenA Penicillin
• Source:
  J Infect Dis. 225(11):1871-1875
• Pubmed ID:
  35266516
• Pubmed Central ID:
  PMC10985786
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/ ; CC/CDC HHSUnited States/
• Volume:
  225
• Issue:
  11
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:8b6c5c149c83478d90668dcdf2dd8c8876d5d30be0fa83df242bd74b3d74a621
• Download URL:
  https://stacks.cdc.gov/view/cdc/153663/cdc_153663_DS1.pdf
• File Type:
  [PDF - 325.26 KB ]