i
Antimicrobial Susceptibility Survey of Invasive Neisseria meningitidis, United States 2012–2016
-
6 01 2022
-
Source: J Infect Dis. 225(11):1871-1875
[PDF-325.26 KB]
Details:
-
Alternative Title:J Infect Dis
-
Personal Author:
-
Description:Background.
Historically, antimicrobial resistance has been rare in US invasive meningococcal disease cases.
Methods.
Meningococcal isolates (n = 695) were collected through population-based surveillance, 2012–2016, and national surveillance, 2015–2016. Antimicrobial susceptibility was assessed by broth microdilution. Resistance mechanisms were characterized using whole-genome sequencing.
Results.
All isolates were susceptible to 6 antibiotics (cefotaxime, ceftriaxone, meropenem, rifampin, minocycline, and azithromycin). Approximately 25% were penicillin or ampicillin intermediate; among these, 79% contained mosaic penA gene mutations. Less than 1% of isolates were penicillin, ampicillin, ciprofloxacin, or levofloxacin resistant.
Conclusions.
Penicillin- and ampicillin-intermediate isolates were common, but resistance to clinically relevant antibiotics remained rare.
-
Subjects:
-
Keywords:
-
Source:
-
Pubmed ID:35266516
-
Pubmed Central ID:PMC10985786
-
Document Type:
-
Funding:
-
Collection(s):
-
Main Document Checksum:
-
Download URL:
-
File Type:
