Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Lepidi, Hubert ; Fournier, Pierre-Edouard ; Raoult, Didier ;
Lepidi, Hubert ; Fournier, Pierre-Edouard ; Raoult, Didier ; Less -
Description:
African tick-bite fever (ATBF) is a rickettsiosis caused by Rickettsia africae. We describe histologic features and immunodetection of R. africae in cutaneous inoculation eschars from 8 patients with ATBF, which was diagnosed by culture or association of positive PCR detection and positive serologic results. We used quantitative image analysis to compare the pattern of inflammation of these eschars with those from Mediterranean spotted fever. We evaluated the diagnostic value of immunohistochemical techniques by using a monoclonal antibody to R. africae. ATBF eschars were histologically characterized by inflammation of vessels composed mainly of significantly more polymorphonuclear leukocytes than are found in cases of Mediterranean spotted fever (p < 0.05). Small amounts R. africae antigens were demonstrated by immunohistochemical examination in 6 of 8 patients with ATBF. Neutrophils in ATBF are a notable component of the host reaction, perhaps because ATBF is a milder disease than the other rickettsioses. Immunohistochemical detection of rickettsial antigens may be useful in diagnosing ATBF.
Subject:
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Adult
African Tick-bite Fever
Animals
Antibodies, Bacterial
Antibodies, Monoclonal
Antigens, Bacterial
Biopsy
Cutaneous Biopsy
Female
Humans
Immunohistochemistry
Male
Middle Aged
Pathology
Polymerase Chain Reaction
Research
Rickettsia
Rickettsia Africae
Rickettsia Infections
Skin
Tick-Borne Diseases
“tâche Noire,” Eschar
Research

Source:
Emerg Infect Dis. 12(9):1332-1337. ;
Document Type:
Journal Article ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:ab254f53dfc1cb858e0a7dc9fb783f7518908b1100b18a918ca0960e2f4acc4e
File Type:

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