Protease-resistant Prion Protein in Lymphoreticular Tumors of Variant Creutzfeldt-Jakob Disease Mice

Cervenakova, Larisa; Yakovleva, Oksana; McKenzie, Carroll

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Protease-resistant Prion Protein in Lymphoreticular Tumors of Variant Creutzfeldt-Jakob Disease Mice

Supporting Files Public Domain

Mar 2006
By Cervenakova, Larisa ; Yakovleva, Oksana ; McKenzie, Carroll

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Cervenakova, Larisa ; Yakovleva, Oksana ; McKenzie, Carroll
Description:

We report protease-resistant prion protein (PrPres) in spontaneous lymphoreticular tumors of mice infected with the agent of variant Creutzfeldt-Jakob disease (vCJD). PrPres may accumulate in lymphoreticular system tumors of asymptomatic persons with vCJD. The statistical power of estimates of vCJD prevalence might be increased by expanding screening to include samples of lymphoreticular neoplasms.
Subjects:

Animals Creutzfeldt-Jakob Syndrome Dispatch Female Humans Lymphoid Tissue Lymphoreticular Tissue Mice Neoplasms Peptide Hydrolases Prions PrPres SJL/OlaHsd Mice Tumor VCJD
Source:

Emerg Infect Dis. 12(3):511-513.
Document Type:

Journal Article
Volume:

12
Issue:

3
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:73c39cc1bf5feac8fb705ff3a4a9d4443509994426492442a7f0f675287bdbbd
Download URL:

https://stacks.cdc.gov/view/cdc/16121/cdc_16121_DS1.pdf
File Type:

[PDF - 82.87 KB ]

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