Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Crampin, Amelia C. ; Glynn, Judith R. ; Traore, Hamidou ; Yates, Malcolm D. ; Mwaungulu, Lorren ; ... More +
Crampin, Amelia C. ; Glynn, Judith R. ; Traore, Hamidou ; Yates, Malcolm D. ; Mwaungulu, Lorren ; Mwenebabu, Michael ; Chaguluka, Steven D. ; Floyd, Sian ; Drobniewski, Francis ; Fine, Paul E.M. Less -
Description:
We conducted the first molecular study of tuberculosis (TB) to estimate the role of household contact and transmission from HIV-positive putative source contacts (PSCs) in a high HIV-prevalence area. TB patients in a long-term population-based study in Malawi were asked about past contact with TB. DNA fingerprinting was used to define clusters of cases with identical strains. Among 143 epidemiologically defined PSC-case pairs, fingerprinting confirmed transmission for 44% of household and family contacts and 18% of other contacts. Transmission was less likely to be confirmed if the PSC were HIV positive than if he or she was HIV negative (odds ratio 0.32, 95% confidence interval [CI] 0.14-0.74). Overall, epidemiologic links were found for 11% of 754 fingerprint-clustered cases. We estimate that 9%-13% of TB cases were attributable to recent transmission from identifiable close contacts and that nearly half of the TB cases arising from recent infection had acquired the infection from HIV-positive patients.
Subject:
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Adult Aids-Related Opportunistic Infections Cluster Analysis DNA Fingerprinting Family Characteristics Female Hiv Infections Hiv Seropositivity Humans Male Middle Aged Molecular Epidemiology Risk Factors Tuberculosis
Source:
Emerg Infect Dis. 12(5):729-735.
Document Type:
Journal Article
Place as Subject:
Malawi
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:c75f819b2948d560ceb66c69353aaf4ccc4e175797545cd7bc17b057b8fe5a58
Download URL:
https://stacks.cdc.gov/view/cdc/15983/cdc_15983_DS1.pdf
File Type:

Supporting Files

• 	05-0789.nxml	txt
  	license.txt	txt

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